{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:23:34Z","timestamp":1778588614355,"version":"3.51.4"},"reference-count":61,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH 5R01NS098590"],"award-info":[{"award-number":["NIH 5R01NS098590"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sensory information is transmitted from peripheral nerves, through the spinal cord, and up to the brain (\u201cbottom up\u201d pathway). Some of this information may be modulated by \u201ctop\u2010down\u201d projections from the brain to the spinal cord. Discovering endogenous mechanisms for reducing pain and itch holds enormous potential for developing new treatments. However, neurons mediating the top\u2010down inhibition of pain are not well understood, nor has any such pathway been identified for itch sensation. Here, we identify a novel population of GABAergic neurons in the ventral brainstem, distinguished by prodynorphin expression, which we named LJA5. LJA5 neurons provide the only known inhibitory projection specifically to lamina I of the spinal cord, which contains sensory neurons that transmit pain and itch information up to the brain. Chemogenetically activating LJA5 neurons in male mice reduces capsaicin\u2010induced pain and histamine\u2010induced itch. Identifying this new pathway opens new treatment opportunities for chronic, refractory pain, and pruritis.<\/jats:p>","DOI":"10.1002\/cne.25076","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T22:55:33Z","timestamp":1606517733000},"page":"2125-2137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Novel inhibitory brainstem neurons with selective projections to spinal lamina I reduce both pain and itch"],"prefix":"10.1002","volume":"529","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8382-6638","authenticated-orcid":false,"given":"Lindsay J.","family":"Agostinelli","sequence":"first","affiliation":[{"name":"Department of Neurology Roy J. and Lucille A. 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