{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:55:14Z","timestamp":1782906914824,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R15DC016407"],"award-info":[{"award-number":["R15DC016407"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R15DC017866"],"award-info":[{"award-number":["R15DC017866"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tonotopy is a prominent feature of the vertebrate auditory system and forms the basis for sound discrimination, but the molecular mechanism that underlies its formation remains largely elusive. Ephrin\/Eph signaling is known to play important roles in axon guidance during topographic mapping in other sensory systems, so we investigated its possible role in the establishment of tonotopy in the mouse cochlear nucleus. We found that ephrin\u2010A3 molecules are differentially expressed along the tonotopic axis in the cochlear nucleus during innervation. Ephrin\u2010A3 forward signaling is sufficient to repel auditory nerve fibers in a developmental stage\u2010dependent manner. In mice lacking ephrin\u2010A3, the tonotopic map is degraded and isofrequency bands of neuronal activation upon pure tone exposure become imprecise in the anteroventral cochlear nucleus. Ephrin\u2010A3 mutant mice also exhibit a delayed second wave in auditory brainstem responses upon sound stimuli and impaired detection of sound frequency changes. Our findings establish an essential role for ephrin\u2010A3 in forming precise tonotopy in the auditory brainstem to ensure accurate sound discrimination.<\/jats:p>","DOI":"10.1002\/cne.25213","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T02:44:07Z","timestamp":1625712247000},"page":"3633-3654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>Ephrin\u2010A3<\/scp>\n                    is required for tonotopic map precision and auditory functions in the mouse auditory brainstem"],"prefix":"10.1002","volume":"529","author":[{"given":"Natalia","family":"Hoshino","sequence":"first","affiliation":[{"name":"Department of Biology Loyola University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazan","family":"Altarshan","sequence":"additional","affiliation":[{"name":"Department of Biology Loyola University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5369-9033","authenticated-orcid":false,"given":"Ahmad","family":"Alzein","sequence":"additional","affiliation":[{"name":"Department of Biology Loyola University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amali M.","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Biology Loyola University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hieu T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Biology Loyola University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma F.","family":"Majewski","sequence":"additional","affiliation":[{"name":"Department of Biology Loyola University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent C.\u2010F.","family":"Chen","sequence":"additional","affiliation":[{"name":"Engineering Program Loyola University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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