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The present study investigated the morphological relationship between P2X3\u2010immunoreactive nerve endings and serosal ganglia in the rat gastric antrum by immunohistochemistry of whole\u2010mount preparations using confocal scanning laser microscopy. P2X3\u2010immunoreactive basket\u2010like subserosal nerve endings with new morphology were distributed laterally to the gastric sling muscles in the distal antrum of the lesser curvature. Parent axons ramified into numerous nerve fibers with pleomorphic flattened structures to form basket\u2010like nerve endings, and the parent axons were originated from large net\u2010like structures of vagal afferent nerve endings. Basket\u2010like nerve endings wrapped around the whole serosal ganglia, which were characterized by neurofilament 200\u2009kDa\u2010immunoreactive neurons with or without neuronal nitric oxide synthase immunoreactivity and S100B\u2010immunoreactive glial cells. Furthermore, basket\u2010like nerve endings were localized in close apposition to dopamine beta\u2010hydroxylase\u2010immunoreactive sympathetic nerve fibers immunoreactive for vesicular nucleotide transporter. These results suggest that P2X3\u2010immunoreactive basket\u2010like nerve endings associated with serosal ganglia are the specialized ending structures of vagal subserosal mechanoreceptors in order to increase the sensitivity during antral peristalsis, and are activated by ATP from sympathetic nerve fibers and\/or serosal ganglia for the regulation of mechanoreceptor function.<\/jats:p>","DOI":"10.1002\/cne.25219","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T12:20:06Z","timestamp":1627042806000},"page":"3866-3881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Morphology of\n                    <scp>P2X3<\/scp>\n                    \u2010immunoreactive basket\u2010like afferent nerve endings surrounding serosal ganglia and close relationship with vesicular nucleotide transporter\u2010immunoreactive nerve fibers in the rat gastric 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