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While these cortical interactions can span the entire LP, subdivisions of the LP are characterized by differential connections with specific cortical regions. In particular, the medial LP has reciprocal connections with frontoparietal cortical areas, including the anterior cingulate cortex (ACC). The ACC plays an integral role in top\u2010down sensory processing and attentional regulation, likely exerting some of these functions via the LP. However, little is known about how ACC and LP interact, and about the information potentially integrated in this reciprocal network. Here, we address this gap by employing a projection\u2010specific monosynaptic rabies tracing strategy to delineate brain\u2010wide inputs to bottom\u2010up LP\u2192ACC and top\u2010down ACC\u2192LP neurons. We find that LP\u2192ACC neurons receive inputs from widespread cortical regions, including primary and higher order sensory and motor cortical areas. LP\u2192ACC neurons also receive extensive subcortical inputs, particularly from the intermediate and deep layers of the superior colliculus (SC). Sensory inputs to ACC\u2192LP neurons largely arise from visual cortical areas. In addition, ACC\u2192LP neurons integrate cross\u2010hemispheric prefrontal cortex inputs as well as inputs from higher order medial cortex. Our brain\u2010wide anatomical mapping of inputs to the reciprocal LP\u2010ACC pathways provides a roadmap for understanding how LP and ACC communicate different sources of information to mediate attentional control and visuomotor functions.<\/jats:p>","DOI":"10.1002\/cne.25317","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T04:44:28Z","timestamp":1649220268000},"page":"1992-2013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Brain\u2010wide mapping of inputs to the mouse lateral posterior (LP\/Pulvinar) thalamus\u2013anterior cingulate cortex network"],"prefix":"10.1002","volume":"530","author":[{"given":"Yi Ning","family":"Leow","sequence":"first","affiliation":[{"name":"Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"McGovern Institute for Brain Research Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria R.","family":"Barlowe","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Wickersham","sequence":"additional","affiliation":[{"name":"McGovern Institute for Brain Research Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mriganka","family":"Sur","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(20000410)419:3<377::AID-CNE9>3.0.CO;2-E"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07251.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe9681"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902320207"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24272"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02157.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-102016-061234"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau7052"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24241-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902170307"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.010"},{"issue":"86","key":"e_1_2_11_13_1","article-title":"Thalamic Circuit Diversity: Modulation of the Driver\/Modulator Framework","volume":"9","author":"Bickford M. 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