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The neurons identified by the expression of the transcription factor Doublesex and mab\u20103 related transcription factor 3 (Dmrt3) have previously been associated with the coordination of locomotion in horses (\n                    <jats:italic>Equus caballus<\/jats:italic>\n                    , Linnaeus, 1758), mice (\n                    <jats:italic>Mus musculus<\/jats:italic>\n                    , Linnaeus, 1758), and zebrafish (\n                    <jats:italic>Danio rerio<\/jats:italic>\n                    , F. Hamilton, 1822). Based on earlier studies, we hypothesized that, in mice, these neurons may be positioned to receive sensory and central inputs to relay processed commands to motor neurons. Thus, we investigated the presynaptic inputs to spinal Dmrt3 neurons using monosynaptic retrograde replication\u2010deficient rabies tracing. The analysis showed that lumbar Dmrt3 neurons receive inputs from intrasegmental neurons, and intersegmental neurons from the cervical, thoracic, and sacral segments. Some of these neurons belong to the excitatory V2a interneurons and to plausible Renshaw cells, defined by the expression of Chx10 and calbindin, respectively. We also found that proprioceptive primary sensory neurons of type Ia2, Ia3, and Ib, defined by the expression of calbindin, calretinin, and Brn3c, respectively, provide presynaptic inputs to spinal Dmrt3 neurons. In addition, we demonstrated that Dmrt3 neurons receive inputs from brain areas involved in motor regulation, including the red nucleus, primary sensory\u2013motor cortex, and pontine nuclei. In conclusion, adult spinal Dmrt3 neurons receive inputs from motor\u2010related brain areas as well as proprioceptive primary sensory neurons and have been shown to connect directly to motor neurons. Dmrt3 neurons are thus positioned to provide sensory\u2013motor control and their connectivity is suggestive of the classical reflex pathways present in the spinal cord.\n                  <\/jats:p>","DOI":"10.1002\/cne.25405","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T11:29:38Z","timestamp":1665401378000},"page":"5-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adult spinal Dmrt3 neurons receive direct somatosensory inputs from ipsi\u2010 and contralateral primary afferents and from brainstem motor nuclei"],"prefix":"10.1002","volume":"531","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-5154","authenticated-orcid":false,"given":"Jennifer","family":"Vieillard","sequence":"first","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2174-6392","authenticated-orcid":false,"given":"Marina C. 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T.","family":"Jakobsson","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9681-5129","authenticated-orcid":false,"given":"Mikaela M.","family":"Ceder","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-2115","authenticated-orcid":false,"given":"Robert E.","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9086-2805","authenticated-orcid":false,"given":"Malin 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