{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:04:42Z","timestamp":1772118282551,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Facial nerve injury in rats have been widely used to study functional and structural changes that occur in the injured motoneurons and other central nervous system structures related with sensorimotor processing. A decrease in long\u2010term potentiation of hippocampal CA3\u2010to\u2010CA1 commissural synapse has recently been reported related to this peripheral injury. Additionally, it has been found increased corticosterone plasmatic levels, impairment in spatial memory consolidation, and hippocampal microglial activation in animals with facial nerve axotomy. In this work, we analyzed the neuronal morphology of hippocampal CA1 and CA3 pyramidal neurons in animals with either reversible or irreversible facial nerve injury. For this purpose, brain tissues of injured animals sacrificed at different postlesion times, were stained with the Golgi\u2010Cox method and compared with control brains. It was found that both reversible and irreversible facial nerve injury\u2010induced significant decreases in dendritic tree complexity, dendritic length, branch points, and spine density of hippocampal neurons. However, such changes\u2019 timing varied according to hippocampal area (CA1 vs. CA3), dendritic area (apical vs. basal), and lesion type (reversible vs. irreversible). In general, the observed changes were transient when animals had the possibility of motor recovery (reversible injury), but perdurable if the recovery from the lesion was impeded (irreversible injury). CA1 apical and CA3 basal dendritic tree morphology were more sensible to irreversible injury. It is concluded that facial nerve injury induced significant changes in hippocampal CA1 and CA3 pyramidal neurons morphology, which could be related to LTP impairments and microglial activation in the hippocampal formation, previously described.<\/jats:p>","DOI":"10.1002\/cne.25455","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T05:37:38Z","timestamp":1673415458000},"page":"663-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Facial nerve axotomy induces morphological changes in hippocampal pyramidal neurons"],"prefix":"10.1002","volume":"531","author":[{"given":"Oscar","family":"Bol\u00edvar\u2010Baquero","sequence":"first","affiliation":[{"name":"Behavioral Neurophysiology Laboratory, \u00a0Physiological Sciences Department, School of Medicine Universidad Nacional de Colombia  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1111-1190","authenticated-orcid":false,"given":"Julieta","family":"Troncoso","sequence":"additional","affiliation":[{"name":"Behavioral Neurophysiology Laboratory, \u00a0Physiological Sciences Department, School of Medicine Universidad Nacional de Colombia  Bogot\u00e1 Colombia"},{"name":"Biology Department School of Sciences Universidad Nacional de Colombia  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20566"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.67804"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01105-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00600.2002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90933-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v36i4.3259"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.6216"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.11.017"},{"key":"e_1_2_10_10_1","unstructured":"D\u00f6rfl J.(1982).The musculature of the mystacial vibrissae of the white mouse. 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