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Understanding the age\u2010associated incidence of natural CNS pathology in a given NHP species is critical to assess the safety of potential treatments for neurodegenerative disorders like Alzheimer's disease (AD). We describe background and age\u2010related neuropathology in the St. Kitts African green monkey (AGM), a recognized translational model for neurodegenerative research, additionally defining the age progression of AD\u2010associated neuropathology in this species. Seventy\u2010one AGM brains were examined, representing age groups of 3\u20136\u00a0years (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a020), 7\u20139\u00a0years (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a020), 10\u201315\u00a0years (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a020), and &gt;15\u00a0years (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a011). A subset of brains (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a031) was assessed immunohistochemically for AD\u2010related pathology, including expressions of A\u03b2, tau, and GFAP. Age\u2010related microscopic findings included hemosiderosis, spheroid formation, neuronal lipofuscinosis and neuromelanosis, white matter and neuropil vacuolation, astrocytosis, and focal microgliosis. Non\u2010age\u2010related findings included perivascular ceroid\u2010laden macrophages, meningeal melanosis, and vascular mineralization. Immunohistochemistry revealed 4G8\u2010immunopositive A\u03b2 plaques and vascular deposits in the prefrontal, frontal, cingulate, and temporal cortices of nine animals over 15\u00a0years of age, with associated increase in GFAP expression. In 12 animals, 11 over the age of 10\u00a0years, phosphorylated tau CP13\u2010immunoreactive neurons, neuropil, and oligodendrocyte\u2010like cells were seen in the prefrontal, frontal, cingulate, orbital, temporal, and entorhinal cortices as well as the hippocampus; no neurofibrillary tangles were observed. AD\u2010related pathology showed an age\u2010related development in cognitive\u2010associated areas in the AGM, highlighting the value of the AGM as a natural model for these neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1002\/cne.25494","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T22:43:44Z","timestamp":1686177824000},"page":"1276-1298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Naturally occurring histological findings and Alzheimer's\u2010like pathology in the brain of aging African green monkeys (\n                    <i>Chlorocebus sabaeus<\/i>\n                    )"],"prefix":"10.1002","volume":"531","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3131-1034","authenticated-orcid":false,"given":"Tatiana M.","family":"Corey","sequence":"first","affiliation":[{"name":"Center for Integrative Mammalian Research Ross University School of Veterinary Medicine  Basseterre Saint Kitts and Nevis"},{"name":"Virscio, Inc.  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