{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:25:33Z","timestamp":1783808733547,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002243","name":"National Ataxia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anatomical studies in animals and imaging studies in humans show that cerebral sensorimotor areas map onto corresponding cerebellar sensorimotor areas and that cerebral association areas map onto cerebellar posterior lobe regions designated as the representation of the association (cognitive and limbic) cerebellum. We report a patient with unilateral left hemispheric status epilepticus, whose brain MRI revealed diffuse unihemispheric cerebral cortical FLAIR and diffusion signal hyperintensity but spared primary motor, somatosensory, visual, and to lesser extent auditory cerebral cortices. Crossed cerebellar diaschisis (dysfunction at a site remote from, but connected to, the location of the primary lesion) showed signal hyperintensity in the right cerebellar posterior lobe and lobule IX, with sparing of the anterior lobe, and lobule VIII. This unique topographic pattern of involvement and sparing of cerebral and cerebellar cortical areas matches the anatomical and functional connectivity specialization in the cerebrocerebellar circuit. This first demonstration of within\u2010hemispheric specificity in the areas affected and spared by cerebrocerebellar diaschisis provides further confirmation in the human brain for topographic organization of connections between the cerebral hemispheres and the cerebellum.<\/jats:p>","DOI":"10.1002\/cne.25534","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T05:15:16Z","timestamp":1692767716000},"page":"2185-2193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diaschisis in the human brain reveals specificity of cerebrocerebellar connections"],"prefix":"10.1002","volume":"531","author":[{"given":"Xavier","family":"Guell","sequence":"first","affiliation":[{"name":"Ataxia Center, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Brain and Cognitive Sciences and McGovern Institute for Brain Research Massachusetts Institute of Technology  Cambridge Massachusetts USA"},{"name":"Department of Neurology New York University Grossman School of Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0706-5125","authenticated-orcid":false,"given":"Jeremy D.","family":"Schmahmann","sequence":"additional","affiliation":[{"name":"Ataxia Center, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_2_8_3_1","first-page":"459","article-title":"Crossed cerebellar diaschisis\u201d in human supratentorial brain infarction","volume":"105","author":"Baron J. C.","year":"1981","journal-title":"Transactions of the American Neurological Association"},{"key":"e_1_2_8_4_1","first-page":"121","article-title":"Zur Anatomie der Schenkel des Kleinhirns insbesondere der Bruckenarne","volume":"4","author":"Bechterew W.","year":"1885","journal-title":"Neurologisches Centralblatt"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000496107"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(79)90082-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00339.2011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu101"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-16-06283.2001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.04014.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23599"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902350306"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-021-01342-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz247"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.07.005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.01.082"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-014-0630-z"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-019-01083-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36652"},{"key":"e_1_2_8_20_1","first-page":"3","volume-title":"Handbook of clinical neurology","author":"Haines D. E.","year":"2012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1544"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(08)60366-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02984610"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-23-08432.2003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.5.1021"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181e1d032"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs354"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40673-015-0023-1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608282113"},{"issue":"10","key":"e_1_2_8_30_1","first-page":"1837","article-title":"Selective neuronal necrosis associated with status epilepticus: MR findings","volume":"21","author":"Men S.","year":"2000","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.6.1013"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.10.1599"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7939688"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2008.07.004"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp157"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/109.4.677"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530230086029"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1996)4:3<174::AID-HBM3>3.0.CO;2-0"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000087786.38997.9E"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0459"},{"key":"e_1_2_8_41_1","volume-title":"MRIAtlas of the Human Cerebellum","author":"Schmahmann J. D.","year":"2000"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-070918-050258"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902890105"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902950212"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903080209"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903260202"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903370107"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(08)60346-3"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20286"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20060"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903120403"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600162"},{"issue":"9","key":"e_1_2_8_53_1","first-page":"4537","article-title":"Human cerebellar sub\u2010millimeter diffusion imaging reveals the motor and non\u2010motor topography of the dentate nucleus","volume":"27","author":"Steele C. J.","year":"2017","journal-title":"Cerebral Cortex"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.065"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.11.042"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90348-6"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.107587"},{"key":"e_1_2_8_58_1","volume-title":"Die Localization Im Grosshirn Und Der Abbau Der Funktion Durch Korticale Herde","author":"Monakow C.","year":"1914"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb15728.x"},{"key":"e_1_2_8_60_1","volume-title":"The primate thalamus","author":"Walker A. E.","year":"1938"},{"key":"e_1_2_8_61_1","doi-asserted-by":"crossref","unstructured":"Washburn S. Onate M. Yoshida J. Vera J. Ramakrishnan K. B. Khatami L. Nadim F. &Khodakhah K.(2022).Cerebellum Directly Modulates the Substantia Nigra Dopaminergic Activity. bioRxiv.https:\/\/doi.org\/10.1101\/2022.05.20.492532","DOI":"10.1101\/2022.05.20.492532"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(79)90004-6"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902370309"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902820107"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970224)378:4<562::AID-CNE10>3.0.CO;2-L"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.25534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T09:14:50Z","timestamp":1705223690000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.25534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,23]]},"references-count":64,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/cne.25534"],"URL":"https:\/\/doi.org\/10.1002\/cne.25534","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/CNE.25534\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25534\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25534\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25534\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25534\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25534\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,23]]},"assertion":[{"value":"2023-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}