{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:06:36Z","timestamp":1772118396368,"version":"3.50.1"},"reference-count":130,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM103503"],"award-info":[{"award-number":["GM103503"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM103412"],"award-info":[{"award-number":["GM103412"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC007695"],"award-info":[{"award-number":["DC007695"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC007695\u2010S1"],"award-info":[{"award-number":["DC007695\u2010S1"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC014393"],"award-info":[{"award-number":["DC014393"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC017080"],"award-info":[{"award-number":["DC017080"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Early postnatal brain development involves complex interactions among maturing neurons and glial cells that drive tissue organization. We previously analyzed gene expression in tissue from the mouse medial nucleus of the trapezoid body (MNTB) during the first postnatal week to study changes that surround rapid growth of the large calyx of Held (CH) nerve terminal. Here, we present genes that show significant changes in gene expression level during the second postnatal week, a developmental timeframe that brackets the onset of airborne sound stimulation and the early stages of myelination. Gene Ontology analysis revealed that many of these genes are related to the myelination process. Further investigation of these genes using a previously published cell type\u2010specific bulk RNA\u2010Seq data set in cortex and our own single\u2010cell RNA\u2010Seq data set in the MNTB revealed enrichment of these genes in the oligodendrocyte lineage (OL) cells. Combining the postnatal day (P)6\u2013P14 microarray gene expression data with the previously published P0\u2013P6 data provided fine temporal resolution to investigate the initiation and subsequent waves of gene expression related to OL cell maturation and the process of myelination. Many genes showed increasing expression levels between P2 and P6 in patterns that reflect OL cell maturation. Correspondingly, the first myelin proteins were detected by P4. Using a complementary, developmental series of electron microscopy 3D image volumes, we analyzed the temporal progression of axon wrapping and myelination in the MNTB. By employing a combination of established ultrastructural criteria to classify reconstructed early postnatal glial cells in the 3D volumes, we demonstrated for the first time that astrocytes within the mouse MNTB extensively wrap the axons of the growing CH terminal prior to OL cell wrapping and compaction of myelin. Our data revealed significant expression of several myelin genes and enrichment of multiple genes associated with lipid metabolism in astrocytes, which may subserve axon wrapping in addition to myelin formation. The transition from axon wrapping by astrocytes to OL cells occurs rapidly between P4 and P9 and identifies a potential new role of astrocytes in priming calyceal axons for subsequent myelination.<\/jats:p>","DOI":"10.1002\/cne.25552","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T08:47:44Z","timestamp":1698914864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Astrocyte ensheathment of calyx\u2010forming axons of the auditory brainstem precedes accelerated expression of myelin genes and myelination by oligodendrocytes"],"prefix":"10.1002","volume":"532","author":[{"given":"Daniel T.","family":"Heller","sequence":"first","affiliation":[{"name":"Department of Medical Engineering University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Kolson","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute West Virginia University School of Medicine  Morgantown West Virginia USA"},{"name":"Department of Otolaryngology, Head and Neck Surgery West Virginia University School of Medicine  Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley N.","family":"Brandebura","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute West Virginia University School of Medicine  Morgantown West Virginia USA"},{"name":"Department of Biochemistry and Molecular Medicine West Virginia University School of Medicine  Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily M.","family":"Amick","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jad","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery West Virginia University School of Medicine  Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Holcomb","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute West Virginia University School of Medicine  Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Deerinck","sequence":"additional","affiliation":[{"name":"National Center for Microscopy and Imaging Research University of California, San Diego  La Jolla California USA"},{"name":"Department of Neuroscience University of California, San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Ellisman","sequence":"additional","affiliation":[{"name":"National Center for Microscopy and Imaging Research University of California, San Diego  La Jolla California USA"},{"name":"Department of Neuroscience University of California, San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Qian","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Mathers","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute West Virginia University School of Medicine  Morgantown West Virginia USA"},{"name":"Department of Otolaryngology, Head and Neck Surgery West Virginia University School of Medicine  Morgantown West Virginia USA"},{"name":"Department of Biochemistry and Molecular Medicine West Virginia University School of Medicine  Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Spirou","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/wics.101"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2015.00049"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0166\u20102236(98)01349\u20106"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102264"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","unstructured":"Bae J. A. Baptiste M. Bodor A. L. Brittain D. Buchanan J. Bumbarger D. J. Castro M. A. Celii B. Cobos E. Collman F. daCosta N. M. Dorkenwald S. Elabbady L. Fahey P. G. Fliss T. Froudarakis E. Gager J. Gamlin C. Halageri A. \u2026Yu S.\u2010C.(2021).Functional connectomics spanning multiple areas of mouse visual cortex.BioRxiv.https:\/\/doi.org\/10.1101\/2021.07.28.454025","DOI":"10.1101\/2021.07.28.454025"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.22452"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010013\u20101492\u20100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0647\u201012.2012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11111773"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.07.056"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.40.9.863"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272205"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(72)90398\u20108"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010physiol\u2010020911\u2010153236"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/celldisc.2017.5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102176"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22633"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.40.3.648"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1059"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90226-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2202580119"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2003.12.008"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4178\u201007.2008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2019.101696"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002605"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418\u2010022\u201002096\u2010y"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp252"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.074252"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R009761"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81044-2"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018579912831"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2016.00083"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4957\u201009.2010"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22859"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.08.016"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2572\u201006.2006"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.490508"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70514"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2004.03604.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9073"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.108.9.2993"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2016.00107"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010019\u20100417\u20100"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20809"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.12.027"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-21606-5"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(93)90015-K"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030159"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5525\u201005.2006"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.198564"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1087\u201013.2013"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20220136"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110599"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102202\u201015\u201059"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.02.006"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00239"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010009\u20108071\u20102"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7526"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021\u2010017\u20109341\u20101"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.18903.1"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz343"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3389\u201012.2013"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.10.016"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896\u20106273(01)80046\u20105"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2004.03791.x"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22306"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v025.i01"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2105"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010021\u201004424\u2010x"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010vision\u2010121219\u2010081753"},{"issue":"3","key":"e_1_2_8_72_1","first-page":"18","article-title":"Classification and regression by randomForest","volume":"2","author":"Liaw A.","year":"2002","journal-title":"R News"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112841"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2467"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.07.005"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6463"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20990"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902220105"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23936"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0788"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946507400113"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09102"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901390102"},{"key":"e_1_2_8_84_1","first-page":"194","article-title":"Ultrastructure of neuroglia","volume":"37","author":"Mugnaini E.","year":"1964","journal-title":"Ergebnisse Der Anatomie Und Entwicklungsgeschichte"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100404.1965.tb01939.x"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.1973.tb07520.x"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20301"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031225"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.8.2.431"},{"key":"e_1_2_8_90_1","volume-title":"The fine structure of the nervous system: Neurons and their supporting cells","author":"Peters A.","year":"1991"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.713651"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617782114"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23473"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.09.006"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3728\u201016.2017"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901530202"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901690303"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903310208"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.044"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.151043"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.053"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20650"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1164\u201021.2022"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201005927\u20107"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83393"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1702290114"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.10.032"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221\u2010003\u20101805\u2010x"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.017"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25828"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00074"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1249766"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1288\u201019.2019"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad3839"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.01.023"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091062498"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2016.00102"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00319179"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001210109"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901330207"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365074"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2008.05.003"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn705"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1034\u201018.2018"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v077.b02"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20415"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00617.2016"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.157"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1860\u201014.2014"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.25552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T15:27:38Z","timestamp":1753025258000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.25552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,2]]},"references-count":130,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cne.25552"],"URL":"https:\/\/doi.org\/10.1002\/cne.25552","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/CNE.25552\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25552\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25552\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25552\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25552\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25552\/v1\/review1","asserted-by":"object"}]},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,2]]},"assertion":[{"value":"2023-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e25552"}}