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This sympathosensory coupling contributes to the onset and persistence of injury\u2010induced chronic pain. We have documented the presence of similar sympathetic plexuses in the trigeminal ganglia of adult mice that ectopically overexpress nerve growth factor (NGF), in the absence of nerve injury. In this study, we sought to further define the phenotype(s) of these trigeminal sensory neurons having sympathetic plexuses in our transgenic mice. Using quantitative immunofluorescence staining analyses, we show that the invading sympathetic axons specifically target sensory somata immunopositive for several biomarkers: NGF high\u2010affinity receptor tyrosine kinase A (trkA), calcitonin gene\u2010related peptide (CGRP), neurofilament heavy chain (NFH), and P2X purinoceptor 3 (P2X3). Based on these phenotypic characteristics, the majority of the sensory somata surrounded by sympathetic plexuses are likely to be NGF\u2010responsive nociceptors (i.e., trkA expressing) that are peptidergic (i.e., CGRP expressing), myelinated (i.e., NFH expressing), and ATP sensitive (i.e., P2X3 expressing). Our data also show that very few sympathetic plexuses surround sensory somata expressing other nociceptive (pain) biomarkers, including substance P and acid\u2010sensing ion channel 3. No sympathetic plexuses are associated with sensory somata that display isolectin B4 binding. Though the cellular mechanisms that trigger the formation of sympathetic plexus (with and without nerve injury) remain unknown, our new observations yield an unexpected specificity with which invading sympathetic axons appear to target a precise subtype of nociceptors. This selectivity likely contributes to pain development and maintenance associated with sympathosensory coupling.<\/jats:p>","DOI":"10.1002\/cne.25563","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T18:14:31Z","timestamp":1700590471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunohistochemical phenotype of sensory neurons associated with sympathetic plexuses in the trigeminal ganglia of adult nerve growth factor transgenic mice"],"prefix":"10.1002","volume":"532","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6607-9791","authenticated-orcid":false,"given":"Hanin","family":"Alsaadi","sequence":"first","affiliation":[{"name":"Center for Neuroscience Studies Queen's University  Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-6109","authenticated-orcid":false,"given":"Jacob","family":"Peller","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Studies Queen's University  Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Ghasemlou","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Studies Queen's University  Kingston Ontario Canada"},{"name":"Department of Anesthesiology and Perioperative Medicine, School of Medicine Queen's University  Kingston Ontario Canada"},{"name":"Department of Biomedical and Molecular Sciences, School of Medicine Queen's University  Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Kawaja","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Studies Queen's University  Kingston Ontario Canada"},{"name":"Department of Biomedical and Molecular Sciences, School of Medicine Queen's University  Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/174480691988449"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2006.11.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-03-01422.1994"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.06.029"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb01143.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S247472"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12418-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08865-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.3.616"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.039990"},{"key":"e_1_2_9_12_1","volume-title":"Medical physiology: A cellular and molecular approach","author":"Boron W. 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