{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:38:46Z","timestamp":1780097926162,"version":"3.54.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In this review, we focus on human\u2010specific features of neocortical neurogenesis in development and evolution. Two distinct topics will be addressed. In the first section, we discuss the expansion of the neocortex during human evolution and concentrate on the human\u2010specific gene\n                    <jats:italic>ARHGAP11B<\/jats:italic>\n                    . We review the ability of ARHGAP11B to amplify basal progenitors and to expand a primate neocortex. We discuss the contribution of\n                    <jats:italic>ARHGAP11B<\/jats:italic>\n                    to neocortex expansion during human evolution and its potential implications for neurodevelopmental disorders and brain tumors. We then review the action of ARHGAP11B in mitochondria as a regulator of basal progenitor metabolism, and how it promotes glutaminolysis and basal progenitor proliferation. Finally, we discuss the increase in cognitive performance due to the ARHGAP11B\u2010induced neocortical expansion. In the second section, we focus on neocortical development in modern humans versus Neanderthals. Specifically, we discuss two recent findings pointing to differences in neocortical neurogenesis between these two hominins that are due to a small number of amino acid substitutions in certain key proteins. One set of such proteins are the kinetochore\u2010associated proteins KIF18a and KNL1, where three modern human\u2010specific amino acid substitutions underlie the prolongation of metaphase during apical progenitor mitosis. This prolongation in turn is associated with an increased fidelity of chromosome segregation to the apical progenitor progeny during modern human neocortical development, with implications for the proper formation of radial units. Another such key protein is transketolase\u2010like 1 (TKTL1), where a single modern human\u2010specific amino acid substitution endows TKTL1 with the ability to amplify basal radial glia, resulting in an increase in upper\u2010layer neuron generation. TKTL1's ability is based on its action in the pentose phosphate pathway, resulting in increased fatty acid synthesis. The data imply greater neurogenesis during neocortical development in modern humans than Neanderthals due to TKTL1, in particular in the developing frontal lobe.\n                  <\/jats:p>","DOI":"10.1002\/cne.25576","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T10:09:22Z","timestamp":1704708562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Neocortical neurogenesis in development and evolution\u2014Human\u2010specific features"],"prefix":"10.1002","volume":"532","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4143-7201","authenticated-orcid":false,"given":"Wieland B.","family":"Huttner","sequence":"first","affiliation":[{"name":"Max Planck Institute of Molecular Cell Biology and Genetics  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0752-8460","authenticated-orcid":false,"given":"Michael","family":"Heide","sequence":"additional","affiliation":[{"name":"German Primate Center Leibniz Institute for Primate Research  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Mora\u2010Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Cell Biology and Genetics  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Namba","sequence":"additional","affiliation":[{"name":"Neuroscience Center, HiLIFE \u2010 Helsinki Institute of Life Science University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3120"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.050"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.09.032"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.11.015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00333"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2310"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-10-1051"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.060"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559\u2010016\u20100069"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.051"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2553"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202254728"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1975"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32332"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1601941"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3494"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0118-z"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5397"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.08.018"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2401"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051209"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119860914"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba9760"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010genom\u2010083117\u2010021441"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.03.070"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41241"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2013.00016"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.04.015"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.3.1242"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44877-x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00512a023"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.08.007"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.06.032"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.230"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18683"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.878950"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn7702"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15793"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.08.051"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.11.027"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.11.014"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.96"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.03.003"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.036"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl6422"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12886"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3291116"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470846631.ch3"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2719"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2630453"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08090"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.10.004"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.1.37"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.02.013"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1197005"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.067"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010cellbio\u2010101011\u2010155801"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200701163"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.01.007"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1242\/Dev.069294"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020107093"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15822"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.25576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T15:27:29Z","timestamp":1753025249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.25576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,8]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/cne.25576"],"URL":"https:\/\/doi.org\/10.1002\/cne.25576","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/CNE.25576\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25576\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25576\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25576\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25576\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25576\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25576\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,8]]},"assertion":[{"value":"2023-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e25576"}}