{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:08:47Z","timestamp":1778915327691,"version":"3.51.4"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Vanadium is a prevalent neurotoxic transition metal with therapeutic potentials in some neurological conditions. Hydrocephalus poses a major clinical burden in neurological practice in Africa. Its primary treatment (shunting) has complications, including infection and blockage; alternative drug\u2010based therapies are therefore necessary. This study investigates the function and cytoarchitecture of motor and cerebellar cortices in juvenile hydrocephalic mice following treatment with varying doses of vanadium. Fifty juvenile mice were allocated into five groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010 each): controls, hydrocephalus\u2010only, low\u2010 (0.15\u00a0mg\/kg), moderate\u2010 (0.3\u00a0mg\/kg), and high\u2010 (3.0\u00a0mg\/kg) dose vanadium groups. Hydrocephalus was induced by the intracisternal injection of kaolin and sodium metavanadate administered by intraperitoneal injection 72hourly for 28 days. Neurobehavioral tests: open field, hanging wire, and pole tests, were carried out to assess locomotion, muscular strength, and motor coordination, respectively. The cerebral motor and the cerebellar cortices were processed for cresyl violet staining and immunohistochemistry for neurons (NeuN) and astrocytes (glial fibrillary acidic protein). Hydrocephalic mice exhibited body weight loss and behavioral deficits. Horizontal and vertical movements and latency to fall from hanging wire were significantly reduced, while latency to turn and descend the pole were prolonged in hydrocephalic mice, suggesting impaired motor ability; this was improved in vanadium\u2010treated mice. Increased neuronal count, pyknotic cells, neurodegeneration and reactive astrogliosis were observed in the hydrocephalic mice. These were mostly mitigated in the vanadium\u2010treated mice, except in the high\u2010dose group where astrogliosis persisted. These results demonstrate a neuroprotective potential of vanadium administration in hydrocephalus. The molecular basis of these effects needs further exploration.\n                  <\/jats:p>","DOI":"10.1002\/cne.25578","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T13:00:03Z","timestamp":1704373203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vanadium administration ameliorates cortical structural and functional changes in juvenile hydrocephalic mice"],"prefix":"10.1002","volume":"532","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-9637","authenticated-orcid":false,"given":"Funmilayo Eniola","family":"Olopade","sequence":"first","affiliation":[{"name":"Department of Anatomy, College of Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omowumi Moromoke","family":"Femi\u2010Akinlosotu","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Opeyemi","family":"Dauda","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Obiako","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6388-5083","authenticated-orcid":false,"given":"James Olukayode","family":"Olopade","sequence":"additional","affiliation":[{"name":"Neuroscience Unit, Department of Veterinary Anatomy, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew Temitayo","family":"Shokunbi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine University of Ibadan  Ibadan Nigeria"},{"name":"Division of Neurological Surgery, Department of Surgery University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"208","article-title":"Recent progress on essentiality of the ultratrace element vanadium in the nutrition of animal and man","volume":"16","author":"Anke M. 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