{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:51:46Z","timestamp":1785887506299,"version":"3.56.0"},"reference-count":147,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD097331"],"award-info":[{"award-number":["R01 HD097331"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01 DC017149"],"award-info":[{"award-number":["R01 DC017149"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    During embryonic development, the olfactory placode (OP) generates migratory neurons, including olfactory pioneer neurons, cells of the terminal nerve (TN), gonadotropin\u2010releasing hormone\u20101 (GnRH\u20101) neurons, and other uncharacterized neurons. Pioneer neurons from the OP induce olfactory bulb (OB) morphogenesis. In mice, GnRH\u20101 neurons appear in the olfactory system around mid\u2010gestation and migrate via the TN axons to different brain regions. The GnRH\u20101 neurons are crucial in controlling the hypothalamic\u2010pituitary\u2010gonadal axis. Kallmann syndrome is characterized by impaired olfactory system development, defective OBs, secretion of GnRH\u20101, and infertility. The precise mechanistic link between the olfactory system and GnRH\u20101 development remains unclear. Studies in humans and mice highlight the importance of the prokineticin\u20102\/prokineticin\u2010receptor\u20102 (Prokr2) signaling pathway in OB morphogenesis and GnRH\u20101 neuronal migration.\n                    <jats:italic>Prokr2<\/jats:italic>\n                    loss\u2010of\u2010function mutations can cause Kallmann syndrome (KS), and hence the Prokr2 signaling pathway represents a unique model to decipher the olfactory\/GnRH\u20101 connection. We discovered that Prokr2 is expressed in the TN neurons during the critical period of GnRH\u20101 neuron formation, migration, and induction of OB morphogenesis. Single\u2010cell RNA sequencing identified that the TN is formed by neurons distinct from the olfactory neurons. The TN neurons express multiple genes associated with KS. Our study suggests that the aberrant development of pioneer\/TN neurons might cause the KS spectrum.\n                  <\/jats:p>","DOI":"10.1002\/cne.25599","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T02:28:03Z","timestamp":1710556083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Illuminating the terminal nerve: Uncovering the link between GnRH\u20101 neuron and olfactory development"],"prefix":"10.1002","volume":"532","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-1170","authenticated-orcid":false,"suffix":"Jr.","given":"Enrico","family":"Amato","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, The Center for Neuroscience Research, The RNA Institute University at Albany, State University of New York Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-4901","authenticated-orcid":false,"given":"Ed Zandro M.","family":"Taroc","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The Center for Neuroscience Research, The RNA Institute University at Albany, State University of New York Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6547-3464","authenticated-orcid":false,"given":"Paolo E.","family":"Forni","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The Center for Neuroscience Research, The RNA Institute University at Albany, State University of New York Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00418-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1995.8.1.73"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131417"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-1-11"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds264"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417438111"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.05.040"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0199"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116047"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.11.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-023-03101-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78448"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq468"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5075-06.2007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.101675"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.139444"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/269338a0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25492"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abh2369"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2021.1893566"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620664114"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws345"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00121"},{"key":"e_1_2_8_26_1","first-page":"166","article-title":"Hypogandotropic hypogonadism with anosmia: The Kallmann syndrome","volume":"7","author":"Christian J. C.","year":"1971","journal-title":"Birth Defects Original Article Series"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2017.00070"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaa120"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4158\/ACCR-2019-0366"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa065"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb36282.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836287"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb36281.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.557341"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13087"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0894"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116142"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0536-x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/19396368.2019.1590478"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-37-1-148"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107621"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.07.004"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2014.09.004"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3238\u201013.2013"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01526190"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(91)90253-2"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(91)90253-2"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-023-02083-7"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113749119"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90243-0"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-17-05281.1996"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2465"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.03.046"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1159\/000288242"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2016.02.008"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03544.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13282"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb36295.x"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.5115\/acb.19.020"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.200448"},{"key":"e_1_2_8_62_1","first-page":"845","article-title":"Kallmann syndrome: MR findings","volume":"14","author":"Knorr J. R.","year":"1993","journal-title":"AJNR American Journal of Neuroradiology"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21067"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.9.3908"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362414"},{"key":"e_1_2_8_66_1","first-page":"266","article-title":"The role of semaphorin signaling in the etiology of hypogonadotropic hypogonadism","volume":"41","author":"Lettieri A.","year":"2016","journal-title":"Minerva Endocrinologica"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107042"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.77259"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.06.007"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00638-8"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.14.6373"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21966"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq4515"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.5.1221"},{"key":"e_1_2_8_75_1","first-page":"31","article-title":"GnRH pulses\u2013the regulators of human reproduction","volume":"104","author":"Marshall J. C.","year":"1993","journal-title":"Transactions of the American Clinical and Climatological Association"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1132787"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508881103"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.06.008"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004291"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1058857"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00133"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13167"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22497"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.04.008"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-017-1456-5"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25389"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2017"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112103"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.03.010"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)12210-9"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-05-02161.1993"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495916"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2019.09.003"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1213098"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23826"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws231"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1159\/000312700"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707173104"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz136"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.8.3402"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1159\/000312703"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2040094.047"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb36298.x"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1086\/302600"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21365"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3192"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2014.11.015"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.173.4001.1036"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(89)90076-4"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/338161a0"},{"key":"e_1_2_8_111_1","first-page":"A168","article-title":"LHRH neurons in the nervus terminalis of the guinea\u2010pig","volume":"196","author":"Schwanzelfukuda M.","year":"1980","journal-title":"Anatomical Record"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901910205"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03094.x"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00035"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-05955.1999"},{"key":"e_1_2_8_116_1","volume-title":"Neuroanatomy, cranial nerve 0 (terminal nerve)","author":"Sonne J.","year":"2020"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz011"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.10.012"},{"key":"e_1_2_8_119_1","article-title":"The human vomeronasal (Jacobson's) organ: A short review of current conceptions, with an english translation of Potiquet's original text","volume":"10","author":"Stoyanov G. S.","year":"2018","journal-title":"Cureus"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i12.2058"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.601923"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00070"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1977-19.2019"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.029074"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200106025"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20594"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00616-5"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/43.6.794"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2010.11.008"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.200210"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00312"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(93)90173-8"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0182"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh029"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24719"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.18.8363"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-42-4-679"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91655-Z"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3022(02)00001-8"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2010.02034.x"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(88)90103-9"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.20.8132"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1320"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.09.051"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-12-07769.1995"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.909623"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100915"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1101\/346502"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.25599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T08:48:43Z","timestamp":1718182123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.25599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":147,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/cne.25599"],"URL":"https:\/\/doi.org\/10.1002\/cne.25599","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/CNE.25599\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25599\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25599\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25599\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25599\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25599\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.25599\/v2\/review1","asserted-by":"object"}]},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e25599"}}