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RGCs also differ by whether their axons target the brain.s ipsilateral or contralateral hemisphere. Contralaterally projecting RGCs (contraRGCs) are widespread in mouse retina, whereas ipsilateral projecting RGCs (ipsiRGCs) are confined to the ventro\u2010temporal (VT) crescent of retina. In this study, we employed the\n                    <jats:italic>Sert\u2010Cre<\/jats:italic>\n                    transgenic line, which had been reported to selectively label ipsiRGCs, to study ipsiRGCs during development. Although the number of Cre\u2010expressing ipsiRGCs did not significantly increase with postnatal age, the region of retina that they occupied did, and by adulthood represented ~30% of the retinal surface. Unexpectedly, genetic ablation of\n                    <jats:italic>Sert\u2010Cre<\/jats:italic>\n                    cells failed to fully disrupt ipsilateral projecting retinal axons, suggesting that not all ipsiRGCs generated Cre in\n                    <jats:italic>Sert\u2010Cre<\/jats:italic>\n                    mice. To test this hypothesis, we retrogradely labeled ipsiRGCs in\n                    <jats:italic>Sert\u2010Cre<\/jats:italic>\n                    mice which revealed that not all ipsiRGCs are labeled in\n                    <jats:italic>Sert\u2010Cre<\/jats:italic>\n                    mice and a small population of contraRGCs flanking the VT crescent generates Cre in this line. These results do not negate the usefulness of the\n                    <jats:italic>Sert\u2010Cre<\/jats:italic>\n                    mouse but do raise important caveats to the interpretation of such studies.\n                  <\/jats:p>","DOI":"10.1002\/cne.25606","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T01:58:56Z","timestamp":1711591136000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Distribution, development, and identity of retinal ganglion cells labeled in the\n                    <i>Sert\u2010Cre<\/i>\n                    reporter mouse"],"prefix":"10.1002","volume":"532","author":[{"given":"Jianmin","family":"Su","sequence":"first","affiliation":[{"name":"Fralin Biomedical Research Institute at Virginia Tech Carilion  Roanoke Virginia USA"},{"name":"School of Neuroscience, College of Science Virginia Tech  Blacksburg Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Byer","sequence":"additional","affiliation":[{"name":"Fralin Biomedical Research Institute at Virginia Tech Carilion  Roanoke Virginia USA"},{"name":"Department of Neuroscience Davidson College  Davidson North Carolina USA"},{"name":"NeuroSURF Program Fralin Biomedical Research Institute at Virginia Tech Carilion  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Liang","sequence":"additional","affiliation":[{"name":"Fralin Biomedical Research Institute at Virginia Tech Carilion  Roanoke Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Fox","sequence":"additional","affiliation":[{"name":"Fralin Biomedical Research Institute at Virginia Tech Carilion  Roanoke Virginia USA"},{"name":"School of Neuroscience, College of Science Virginia Tech  Blacksburg Virginia USA"},{"name":"Department of Biological Sciences, College of Science Virginia Tech  Blacksburg Virginia USA"},{"name":"Department of Biology, College of Natural Sciences University of Massachusetts Amherst  Amherst Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.07.064"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16468"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22381"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901910306"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.05.023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1422\u201012.2012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111040"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02033"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.04.07.536039"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn0504\u2010483"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(03)00684\u20106"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.09.009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20162"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523805225154"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.03.010"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0907\u201011.2011"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06739"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.05.045"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14682"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09\u20104098"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201052215\u20104"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.002"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.04.26.489554"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010vision\u2010091517\u2010034306"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57458"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10894"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","unstructured":"Negueruela S. 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