{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:24:36Z","timestamp":1787315076519,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Like the cerebralcortex, the surface of the cerebellum is repeatedly folded. Unlike the cerebralcortex, however, cerebellar folds are much thinner and more numerous; repeatthemselves largely along a single direction, forming accordion\u2010like folds transverseto the mid\u2010sagittal plane; and occur in all but the smallest cerebella. We haveshown previously that while the location of folds in mammalian cerebral cortex isclade\u2010specific, the overall degree of folding strictly follows a universalpower law relating cortical thickness and the exposed and total surface areas predictedfrom the minimization of the effective free energy of an expanding, self\u2010avoidingsurface of a certain thickness. Here we show that this scaling law extends tothe folding of the mid\u2010sagittal sections of the cerebellum of 53 speciesbelonging to six mammalian clades. Simultaneously, we show that each clade hasa previously unsuspected distinctive spatial pattern of folding evident at themid\u2010sagittal surface of the cerebellum. We note, however, that the mammaliancerebellum folds as a multi\u2010fractal object, because of the difference betweenthe outside\u2010in development of the cerebellar cortex around a preexisting coreof already connected white matter, compared to the inside\u2010out development ofthe cerebral cortex with a white matter volume that develops as the cerebralcortex itself gains neurons. We conclude that repeated folding, one of the mostrecognizable features of biology, can arise simply from the interplay betweenthe universal applicability of the physics of self\u2010organization and biological,phylogenetical clade\u2010specific contingency, without the need for invokingselective pressures in evolution.<\/jats:p>","DOI":"10.1002\/cne.25616","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T07:25:46Z","timestamp":1713425146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Folding of the cerebellar cortex is clade\u2010specific in form but universal in degree"],"prefix":"10.1002","volume":"532","author":[{"given":"Annaleigh R.","family":"York","sequence":"first","affiliation":[{"name":"Department of Psychology Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chet C.","family":"Sherwood","sequence":"additional","affiliation":[{"name":"Department of Anthropology The George Washington University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1881-2854","authenticated-orcid":false,"given":"Paul R.","family":"Manger","sequence":"additional","affiliation":[{"name":"School of Anatomical Sciences Faculty of Health Sciences University of the Witswatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-1192","authenticated-orcid":false,"given":"Jon H.","family":"Kaas","sequence":"additional","affiliation":[{"name":"Department of Psychology Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Brain Institute Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Mota","sequence":"additional","affiliation":[{"name":"Institute of Physics Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-3599","authenticated-orcid":false,"given":"Suzana","family":"Herculano\u2010Houzel","sequence":"additional","affiliation":[{"name":"Department of Psychology Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Brain Institute Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"448","article-title":"The mammalian cerebellum: Its lobes and fissures","volume":"38","author":"Bradley O. 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