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These have been used to construct in vivo and postmortem diagnostic and staging classifications for evaluating the spectrum of AD in the \u201cATN\u201d and \u201cABC\u201d (\u201cB\u201d for Braak tau stage, \u201cC\u201d for Consortium to Establish a Registry for Alzheimer's Disease [CERAD] neuritic plaque density) systems. Another common AD feature involves cerebral amyloid angiopathy (CAA). We report the first experiment to examine relationships among cognition, brain distribution of amyloid plaques, CAA, tau\/tangles, and magnetic resonance imaging (MRI)\u2010determined volume changes (as a measure of \u201cN\u201d) in the same group of behaviorally characterized nonhuman primates. Both ATN and ABC systems were applied to a group of 32 rhesus macaques aged between 7 and 33 years. When an immunohistochemical method for \u201cT\u201d and \u201cB\u201d was used, some monkeys were \u201ctriple positive\u201d on ATN, with a maximum ABC status of A1B2C3. With silver or thioflavin S methods, however, all monkeys were classified as T\u2010negative and B0, indicating the absence of mature neurofibrillary tangles (NFTs) and hence neuropathologically defined AD. Although monkeys at extremes of the ATN and ABC classifications, or with frequent CAA, had significantly lower scores on some cognitive tests, the lack of fully mature NFTs or dementia\u2010consistent cognitive impairment indicates that fully developed AD may not occur in rhesus macaques. There were sex differences noted in the types of histopathology present, and only CAA was significantly related to gray matter volume.<\/jats:p>","DOI":"10.1002\/cne.25670","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T04:43:47Z","timestamp":1727153027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Human Alzheimer's Disease ATN\/ABC Staging Applied to Aging Rhesus Macaque Brains: Association With Cognition and MRI\u2010Based Regional Gray Matter Volume"],"prefix":"10.1002","volume":"532","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8122-9007","authenticated-orcid":false,"given":"Carol A.","family":"Barnes","sequence":"first","affiliation":[{"name":"Departments of Psychology, Neurology and Neuroscience, Evelyn F. McKnight Brain Institute University of Arizona, Tucson  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele R.","family":"Permenter","sequence":"additional","affiliation":[{"name":"California National Primate Center University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Vogt","sequence":"additional","affiliation":[{"name":"California National Primate Center University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Chen","sequence":"additional","affiliation":[{"name":"Arizona State University  Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Beach","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Banner Sun Health Research Institute  Sun City Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306\u20104522(89)90292\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1852\u201007.2008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00158a027"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.631"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(91)90048-O"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166\u20104328(86)90225\u20101"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021\u2010014\u20109258\u2010x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03331975"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/33.6.858"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2023.06.011"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056593"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20104159.1995.64020749.x"},{"key":"e_1_2_9_14_1","first-page":"83","article-title":"Microcebus Murinus, A Convenient Laboratory Animal for the Study of Alzheimer's Disease","volume":"1","author":"Bons N.","year":"1995","journal-title":"Alzheimer's Research"},{"issue":"7","key":"e_1_2_9_15_1","first-page":"741","article-title":"Immunocytochemical Characterization of Tau Proteins During Cerebral Aging of the Lemurian Primate Microcebus Murinus","volume":"318","author":"Bons N.","year":"1995","journal-title":"Comptes Rendus De L'acad\u00e9mie Des Sciences. 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