{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:03:50Z","timestamp":1772118230813,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Direction selectivity is a fundamental feature in the visual system. In the retina, direction selectivity is independently computed by ON and OFF circuits. However, the advantages of extracting directional information from these two independent circuits are unclear. To gain insights, we examined the ON\u2013OFF direction\u2010selective ganglion cells (DSGCs), which recombine signals from both circuits. Specifically, we investigated the dendritic architecture of these neurons with the premise that asymmetries in architecture will provide insights into function. Scrutinizing the dendrites of dye\u2010filled ON\u2013OFF DSGCs reveals that the OFF arbors of these neurons are substantially denser. The increase in density can be primarily attributed to the higher branching seen in OFF arbors. Further, analysis of ON\u2013OFF DSGCs in a previously published serial block\u2010face electron microscopy dataset revealed that the denser OFF arbors packed more bipolar synapses per unit dendritic length. These asymmetries in the dendritic architecture suggest that the ON\u2013OFF DSGC preferentially magnifies the synaptic drive of the OFF pathway, potentially allowing it to encode information distinct from the ON pathway.<\/jats:p>","DOI":"10.1002\/cne.70023","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T23:06:16Z","timestamp":1738019176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetries in the Architecture of ON and OFF Arbors in ON\u2013OFF Direction\u2010Selective Ganglion Cells"],"prefix":"10.1002","volume":"533","author":[{"given":"Sheba Annie","family":"Philip","sequence":"first","affiliation":[{"name":"Department of Biotechnology Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narendra Pratap","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7154-2681","authenticated-orcid":false,"given":"Saranya","family":"Viswanathan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Parida","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6199-1221","authenticated-orcid":false,"given":"Santhosh","family":"Sethuramanujam","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras  Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91167-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902800108"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014105"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16468"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.04.040"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.170704"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09818"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21053"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02737.2002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.4.1127"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.20.9666"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00108.2004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18609"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903240303"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111040"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42392"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.81780"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110106"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10268-z"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.271148"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2804-16.2016"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110410"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.52949"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13240"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.77.2.675"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40527-z"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.08.048"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4554-15.2016"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(93)90181-U"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5616-09.2010"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00360.2015"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.019"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.013"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4013-15.2016"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0564-11.2011"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3824-15.2016"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.05.015"},{"key":"e_1_2_9_39_1","volume-title":"Retinal Computation","author":"Schwartz G.","year":"2021"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3225"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP275073"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21680-9"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.041"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.09.058"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.033"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3066-18.2019"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.05.030"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.03.054"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10323"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.06.020"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.05.006"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-11-06301.1994"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3165"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.020"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1981.0033"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1981.0032"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-091517-034048"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.076695"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-09-05267.1994"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-07-02645.2003"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5602-08.2009"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.70023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T02:26:09Z","timestamp":1744251969000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.70023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/cne.70023"],"URL":"https:\/\/doi.org\/10.1002\/cne.70023","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/CNE.70023\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.70023\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.70023\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.70023\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.70023\/v2\/response1","asserted-by":"object"}]},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70023"}}