{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:03:30Z","timestamp":1790960610533,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The p75NTR receptor, a member of the tumor necrosis factor (TNF) receptor superfamily, can participate in signaling pathways either by forming heteromeric complexes with other receptors, such as the Trk family (tropomyosin receptor kinases), or by functioning independently. p75NTR was investigated prevalently in the brain and retina of mammals, whereas almost nothing is known about its conservation among species. Here, we reconstructed the phylogenetic arb of p75NTR and described for the first time the p75NTR expression in the brain of the basal vertebrate Chondrichthyan <jats:italic>Scyliorhinus canicula<\/jats:italic> (<jats:italic>S. canicula<\/jats:italic>), uncovering the existing parallelism between ancient vertebrates and mammals. p75NTR functional conservation among vertebrates was further investigated by cloning the <jats:italic>S. canicula<\/jats:italic> nerve growth factor (NGF) and performing the canonical posterior commissure (PC)\u201012 differentiation assay, which results in standard neurite\u2010like production. We then investigated the <jats:italic>S. canicula<\/jats:italic> p75NTR, which proves to be capable of complementing a specific clone of PC\u201012 lacking p75NTR (PC\u201012 p75NTR<jats:sup>\u2212<\/jats:sup>\/<jats:sup>\u2212<\/jats:sup>). All together, our results highlighted the expression and functional conservation of p75NTR among vertebrates during the evolution.<\/jats:p>","DOI":"10.1002\/cne.70049","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T21:23:05Z","timestamp":1744492985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nerve Growth Factor Receptor (NGFR\/p75NTR) of the Small\u2010Spotted Catshark (<i>Scyliorhinus canicula<\/i>): Evolutionary Conservation and Brain Function"],"prefix":"10.1002","volume":"533","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-3635","authenticated-orcid":false,"given":"Elena","family":"Chiavacci","sequence":"first","affiliation":[{"name":"Biology Laboratory (BIO@SNS) Scuola Normale Superiore  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Camera","sequence":"additional","affiliation":[{"name":"Biology Laboratory (BIO@SNS) Scuola Normale Superiore  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Costa","sequence":"additional","affiliation":[{"name":"Neuroscience Institute National Research Council (CNR)  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baldassare","family":"Fronte","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Terzibasi","family":"Tozzini","sequence":"additional","affiliation":[{"name":"Biology and Evolution of Marine Organisms Department (BEOM) Stazione Zoologica Anton Dohrn  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cellerino","sequence":"additional","affiliation":[{"name":"Biology Laboratory (BIO@SNS) Scuola Normale Superiore  Pisa Italy"},{"name":"Fritz Lipmann Institute for Age Research Leibniz Institute  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043650"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-03-00941.1993"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(91)90097-V"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3008331"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960610)369:4<591::AID-CNE8>3.0.CO;2-#"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-19-07288.1997"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119495"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.21075"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800011573"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adn2616"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(07)00371-5"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000048725"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90155-9"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2016.11.005"},{"key":"e_1_2_11_16_1","first-page":"373","volume-title":"Advances in Cellular Neurobiology","author":"Greene L. 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