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Each of the vestibular end organs has specialized neuroepithelia with both regular and irregular afferents. In otolith organs, the utricle and saccule, afferents\u00a0most responsive to linear jerk (jerk\u2014derivative of acceleration) are located in the striola and project centrally to the vestibular nuclear complex (VNC) as well as the uvula and nodulus of the vestibulocerebellum (VeCb). The pattern of central neuronal activation attributed to otolith irregular afferents is relatively unknown. To address this gap, c\u2010Fos was used as a marker of neuronal activity to map the distribution of active neurons throughout the rostro\u2010caudal extent of the VNC and VeCb in rats. Immunohistochemistry for c\u2010Fos was performed to assess activation of VNC and VeCb neurons in response to a linear jerk stimulus delivered in the naso\u2010occipital plane. Activated neurons were distributed throughout the VNC, including the lateral vestibular nucleus (LVe), magnocellular medial vestibular nucleus (MVeMC), parvocellular medial vestibular nucleus (MVePC), spinal vestibular nucleus (SpVe), and superior vestibular nucleus (SuVe). Notably, after stimulation, the MVePC exhibited the greatest number of c\u2010Fos\u2010labeled nuclei. Significant increases in c\u2010Fos labeling were found in mid\u2010rostro\u2010caudal and caudal regions of the VNC in the LVe, MVe, and SpVe. Additionally, c\u2010Fos labeling was observed across all regions of the VeCb after jerk stimulation. Significant increases in the number of labeled nuclei were found throughout the rostro\u2010caudal extent of the nodulus and uvula. The distribution of neuronal activity suggests that regions receiving the greatest direct otolith input exhibit the most substantial changes in response to otolith\u2010derived, irregular fiber stimulation.<\/jats:p>","DOI":"10.1002\/cne.70059","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:34:56Z","timestamp":1747647296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Otolith Irregular Fiber Stimulation Elicits a Rostro\u2010Caudal Activity Gradient in the Vestibular Nuclear Complex and Both Direct and Indirect Afferent Pathways of the Vestibulocerebellum"],"prefix":"10.1002","volume":"533","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6225-1700","authenticated-orcid":false,"given":"Avril Genene","family":"Holt","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Visual, and Anatomical Sciences Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"John D. Dingell VAMC  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shana","family":"King","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual, and Anatomical Sciences Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1826-9994","authenticated-orcid":false,"given":"Syed Danial","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual, and Anatomical Sciences Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"John D. Dingell VAMC  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod D.","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual, and Anatomical Sciences Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"John D. Dingell VAMC  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Michael","family":"King","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06637.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(03)00055-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb25222.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-013-3602-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2604-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.12.001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00031.2019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00117"},{"key":"e_1_2_11_10_1","article-title":"Complications Associated With Prone Positioning in Neurosurgery: A Systematic Review","volume":"66","author":"Silva Brito J.","year":"2021","journal-title":"Arquivos M\u00e9dicos"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.07.053"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-382163-8.00037-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050033"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.06.051"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00883.2018"},{"key":"e_1_2_11_16_1","volume-title":"Fundamental Neuroscience for Basic and Clinical Applications","author":"Haines D. 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