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One monkey received rehabilitation of the severely affected (contralesional) hand to model traditional poststroke therapeutic intervention. The second monkey received the same rehabilitation paradigm, but of the less affected (ipsilesional) hand, to model patients who preferentially use their ipsilesional hand or develop learned nonuse of the contralesional hand. Changes in the terminal distribution of the corticospinal projection (CSP) at C5\u2013T1 from spared supplementary motor cortex (M2) were studied using high\u2010resolution anterograde tracers and stereology. M2 CSP findings were compared to the M2 CSP in animals receiving the same sensorimotor cortical lesion but with no rehabilitative intervention (natural recovery;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a04), and controls (no lesion\u2010no rehabilitation;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a05). Rehabilitation of the severely affected hand induced massive upregulation of contralateral M2 CSP terminals compared to naturally recovered and control groups. Terminal increases occurred in lamina VII compared to both groups, and in the dorsomedial and dorsolateral quadrants of motoneuron lamina IX compared to the naturally recovered lesion group. In contrast, rehabilitating the less affected hand induced substantial contralateral terminal loss compared to both groups. Our findings demonstrate that long\u2010term rehabilitation of the severely impaired hand following sensorimotor cortex injury promotes spared M2 corticospinal sprouting, possibly reflecting favorable corticospinal adaptations accompanying repetitive upper\u2010limb rehabilitation in some stroke patients. Extensive M2 CSP loss following rehabilitation of the less impaired hand indicates a risk of losing spared CSPs in patients who preferentially use their ipsilesional hand or develop learned nonuse.\n                  <\/jats:p>","DOI":"10.1002\/cne.70123","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:45:42Z","timestamp":1767181542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Hand Rehabilitation After Sensorimotor Cortical Injury Promotes Massive Upregulation of Corticospinal Terminations From Spared Supplementary Motor Cortex in\n                    <i>Macaca mulatta<\/i>"],"prefix":"10.1002","volume":"534","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-5728","authenticated-orcid":false,"given":"Robert J.","family":"Morecraft","sequence":"first","affiliation":[{"name":"Laboratory of Neurological Sciences, Division of Biomedical and 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Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"Pizzimenti","sequence":"additional","affiliation":[{"name":"Motor Control Laboratories, Department of Health and Human Physiology The University of Iowa  Iowa City Iowa USA"},{"name":"Department of Anatomy and Cell Biology, Carver College of Medicine The University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren G.","family":"Darling","sequence":"additional","affiliation":[{"name":"Motor Control Laboratories, Department of Health and Human Physiology The University of Iowa  Iowa City Iowa 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