{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:55:51Z","timestamp":1789232151010,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The mesodiencephalic junction (MDJ) is located in a caudorostrally elongated, column\u2010shaped region encompassing the medial accessory oculomotor nucleus and perirubral area. It relays cerebral projections to the rostral subnuclei of the inferior olive (IO), which, in turn, send climbing fibers to the cerebellar hemisphere and receive nucleo\u2010olivary projections from the cerebellar nuclei (CN), forming a parallel, loop\u2010shaped, modular circuitry. However, the topographical organization of the MDJ\u2013IO projection, which may contribute to functional localization within the cerebellar hemisphere, has not been fully elucidated. Here, we analyzed the distribution of labeled neurons in the MDJ in relation to those in the CN by injecting a Lumafluor retrograde tracer into various sites within the rostral IO subnuclei of mice. Injections mainly targeting the lateral or medial parts of the rostral IO subnuclei labeled neurons predominantly in the ventral or dorsal CN, respectively (referred to as v\u2010 and d\u2010CN\u2010predominant injection cases). Correspondingly, v\u2010CN\u2010predominant injection cases labeled neurons in the rostromedial, centroventral, and caudolateral regions of the MDJ, collectively termed the \u201csheathing subarea,\u201d whereas d\u2010CN\u2010predominant injection cases labeled neurons primarily in the central \u201cshaft subarea\u201d of the MDJ. Considering the previously reported lobule\u2010related topography among the IO, cerebellar cortex, and CN, the sheathing and shaft subareas of the MDJ are likely to project preferentially to crus I and to other neighboring cerebellar hemispheric lobules, respectively. We speculate that the sheathing subarea of the MDJ is more strongly involved in non\u2010somatosensorimotor cognitive functions than the shaft subarea.<\/jats:p>","DOI":"10.1002\/cne.70167","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:53:51Z","timestamp":1779724431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Topographical Relationship in the Mesodiencephalic Projection to the Inferior Olive Linked With Cerebellar Hemispheric Lobules in Mice"],"prefix":"10.1002","volume":"534","author":[{"given":"Ji","family":"Qing","sequence":"first","affiliation":[{"name":"Department of Cognitive Neurobiology Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Bunkyo\u2010ku Tokyo Japan"},{"name":"Former Department of Systems Neurophysiology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Bunkyo\u2010ku Tokyo 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