{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:53:59Z","timestamp":1790315639472,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19NS130608"],"award-info":[{"award-number":["U19NS130608"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031647","name":"Gr\u00fcnenthal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The voltage\u2010gated sodium channel Na\n                    <jats:sub>V<\/jats:sub>\n                    1.7 is a pain target supported by human genetics, and many compounds have been developed to inhibit Na\n                    <jats:sub>V<\/jats:sub>\n                    1.7 but have disappointed in clinical trials due to cardiovascular effects. Because some recent reports suggest that pharmacological inhibition of Na\n                    <jats:sub>V<\/jats:sub>\n                    1.7 in the rodent spinal dorsal horn can achieve pain relief, we sought to better understand Na\n                    <jats:sub>V<\/jats:sub>\n                    1.7 expression in the human spinal cord. We report that Na\n                    <jats:sub>V<\/jats:sub>\n                    1.7 mRNA is expressed in putative projection neurons (NK1R+, GPR83+) in the human spinal dorsal horn, predominantly in lamina I and II, as well as in deep dorsal horn neurons. Na\n                    <jats:sub>V<\/jats:sub>\n                    1.7 mRNA was also detected in preganglionic parasympathetic and sympathetic neurons, motor neurons in the ventral horn, and ependymal cells lining the central canal. Na\n                    <jats:sub>V<\/jats:sub>\n                    1.7 protein was predominantly found in the central axons of sensory neurons terminating in lamina I\u2013II and colocalized, in part, with presynaptic markers like Bassoon and CGRP. Postsynaptically, Na\n                    <jats:sub>V<\/jats:sub>\n                    1.7 protein was detectable in the soma of motor neurons but was more elusive in dorsal horn populations due to the abundance of presynaptic signal. However, Na\n                    <jats:sub>V<\/jats:sub>\n                    1.7 protein was detected in the axon initial segment of some resident dorsal horn neurons and in axons entering the anterior commissure. Given that projection neurons are critical for conveying nociceptive information from the dorsal horn to the brain, these data support that dorsal horn Na\n                    <jats:sub>V<\/jats:sub>\n                    1.7 expression may play an unappreciated role in pain phenotypes observed in humans with genetic\n                    <jats:italic>SCN9A<\/jats:italic>\n                    mutations.\n                  <\/jats:p>","DOI":"10.1002\/cne.70168","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:54:44Z","timestamp":1778860484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Na\n                    <sub>V<\/sub>\n                    1.7 mRNA and Protein Expression in Resident Neurons of the Human Spinal Dorsal Horn"],"prefix":"10.1002","volume":"534","author":[{"given":"Stephanie","family":"Shiers","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Center for Advanced Pain Studies The University of Texas at Dallas  Richardson Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nwasinachi A.","family":"Ezeji","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Center for Advanced Pain Studies The University of Texas at Dallas  Richardson Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Lima\u2010Truax","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Krajewski","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Funk","sequence":"additional","affiliation":[{"name":"Southwest Transplant Alliance  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Cervantes","sequence":"additional","affiliation":[{"name":"Southwest Transplant Alliance  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Horton","sequence":"additional","affiliation":[{"name":"Southwest Transplant Alliance  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Dussor","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Center for Advanced Pain Studies The University of Texas at Dallas  Richardson Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Hennen","sequence":"additional","affiliation":[{"name":"Gr\u00fcnenthal Gmbh  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore J.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Center for Advanced Pain Studies The University of Texas at Dallas  Richardson Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Allen Institute for Brain Science.2022a.Allen Human Brain Atlas [SCN9A].Allen Institute for Brain Science."},{"key":"e_1_2_9_3_1","unstructured":"Allen Institute for Brain Science.2022b. \u201cAllen Mouse Brain Atlas [Scn9a].\u201dmouse.brain\u2010map.org."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax4568"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2021.750583"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2021.02.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424\u2010020\u201002419\u20109"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","unstructured":"Bell A. M. C.Utting A. C.Dickie et\u00a0al.2023. \u201cDeep Sequencing of Phox2a Nuclei Reveals Five Classes of Anterolateral System Neurons.\u201d bioRxiv.https:\/\/doi.org\/10.1101\/2023.08.20.553715.","DOI":"10.1101\/2023.08.20.553715"},{"key":"e_1_2_9_9_1","unstructured":"Biogen.2021.Biogen Announces Positive Topline Results from Phase 2 CONVEY Study in Small Fiber Neuropathy.Biogen."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744\u20108069\u20108\u201082"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21527"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756\u2010199503000\u201000005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903560302"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000270"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328337310a"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264\u2010017\u20100132\u20103"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002171"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.01.018"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102860\u20101"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05413"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21154"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3404"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S388896"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15327"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22485"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.10.006"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1091096"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2023.2289256"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105895"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09160"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4064\u201011.2011"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806919881846"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806919858801"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3937\u201003.2004"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010022\u201001302\u2010z"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902600303"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573\u2010019\u201000065\u20100"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay1050"},{"key":"e_1_2_9_39_1","volume-title":"StatPearls","author":"Ku J.","year":"2022"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09087"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05453"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1922\u201017.2018"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0899\u201017.2017"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010020\u201002156\u20101"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/17448069251342409"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.03.012"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13891"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5336.275"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306\u20104522(95)00558\u20107"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.047"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001227"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab482"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16398"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac078"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000408"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025125\u20101"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/14734220309424"},{"key":"e_1_2_9_58_1","volume-title":"Atlas of the Spinal Cord of the Rat, Mouse, Marmoset, Rhesus, and Human","author":"Sengul G.","year":"2013"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1049\u201018.2018"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001973"},{"key":"e_1_2_9_61_1","doi-asserted-by":"crossref","unstructured":"Shiers S. M. S.Yousuf J.Mwirigi A.Cervantes andT.Price.2024. \u201cHuman Ganglia and Spinal Cord Tissue Procurement From Organ Donors and Tissue Quality Assessment.\u201d protocols.io.https:\/\/doi.org\/10.17504\/protocols.io.kqdg32qr1v25\/v1.","DOI":"10.17504\/protocols.io.kqdg32qr1v25\/v1"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25122"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806918782323"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460\u20109568.2000.00950.x"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.111"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901880404"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.01.007"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.012153"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.70168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cne.70168","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.70168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T05:49:07Z","timestamp":1784526547000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.70168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/cne.70168"],"URL":"https:\/\/doi.org\/10.1002\/cne.70168","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/CNE.70168\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.70168\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.70168\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/CNE.70168\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70168"}}