{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:29:12Z","timestamp":1787588952329,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DC019634"],"award-info":[{"award-number":["R01DC019634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31DC021084"],"award-info":[{"award-number":["F31DC021084"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mechanosensory innervation of the oral cavity enables us to detect the texture and location of the foods we consume. Our goal was to find a genetic identifier for a mechanoreceptive subtype. Toward this goal, we examined neurons expressing the neurotrophin receptor TrkC (TrkC\u2010tdTomato), parvalbumin (Pvalb), or glutamate transporter, Vglut3. We found that the majority of Pvalb\u2010lineage, Vglut3\u2010lineage, and TrkC\u2010tdTomato neurons innervating the tongue are separate trigeminal neuron populations. Because different papilla types contribute to food detection in different ways, we examined the innervation patterns of these neuron subtypes. We found that Pvalb\u2010lineage and Vglut3\u2010lineage neurons were fungiform papilla\u2010specific, whereas TrkC+ fibers innervated both papilla types. We found that all Pvalb\u2010lineage nerve fibers are labeled with neurofilament heavy chain (NFH), have axons that are surrounded by myelin basic protein, and lack calcitonin gene\u2010related peptide. This indicates that these are all myelinated neurons. In contrast, Vglut3\u2010lineage and TrkC\u2010tdTomato nerve fibers were a mixed population of NFH+ nerve fibers and NFH\u2212 nerve fibers, as well as myelinated and unmyelinated nerve fibers. When we examined the axonal ending morphologies of the three genetic populations, we found that the Pvalb\u2010lineage neurons consistently displayed a \u201cbasket\u2010like\u201d axonal ending that surrounded the taste bud. While TrkC+ and Vglut3\u2010lineage neurons sometimes displayed this \u201cbasket\u2010like\u201d axonal ending, other axonal endings lacked this structure. When compared across groups, the Vglut3\u2010lineage axonal endings displayed the greatest degree of morphological variability. Collectively, these data show that Pvalb\u2010lineage may be a genetic identifier for a single myelinated mechanoreceptor innervating fungiform papillae.<\/jats:p>","DOI":"10.1002\/cne.70186","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:32:25Z","timestamp":1785144745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anatomical Characteristics of Tongue\u2010Innervating Mechanoreceptors"],"prefix":"10.1002","volume":"534","author":[{"given":"Thomas A.","family":"Myers","sequence":"first","affiliation":[{"name":"Department of Anatomical Sciences and Neurobiology University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Sneve","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences and Neurobiology University of Louisville School of Medicine  Louisville 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