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Somatostatin\u2010positive (SST+) Martinotti interneurons, which regulate pyramidal cell activity in the medial prefrontal cortex (mPFC), are particularly relevant for inhibitory control, yet their age\u2010related vulnerability remains poorly understood. Here, we examined GFP\u2010labeled SST+ interneurons in mice at 3, 9, and 16\u00a0months of age, focusing on neuronal density, dendritic arborization, and expression of NMDA receptor subunits GluN1 and GluN2B. Our findings reveal a significant decline in SST+ interneuron density in aged male mice, whereas female mice displayed an increase in dendritic arborization with age. Analysis of NMDA receptor puncta showed a reduction in GluN1 and GluN2B density with increased puncta size in older animals. Together, these findings reveal age\u2010 and sex\u2010dependent structural and molecular remodeling of SST+ interneurons in the mPFC.<\/jats:p>","DOI":"10.1002\/cne.70217","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:49:51Z","timestamp":1792054191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010Related Changes in Density, Arborization, and NMDA Receptor Expression in Somatostatin Interneurons of the Mouse mPFC"],"prefix":"10.1002","volume":"534","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7103-6548","authenticated-orcid":false,"given":"Blanca","family":"S\u00e1nchez\u2010Moreno","sequence":"first","affiliation":[{"name":"Department of Anatomy, Histology and Neuroscience, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain"},{"name":"PhD Program in Neuroscience Cajal\u2010UAM, School of Medicine Universidad Aut\u00f3noma de Madrid  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