{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:19:23Z","timestamp":1789985963774,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,14]],"date-time":"2004-10-14T00:00:00Z","timestamp":1097712000000},"content-version":"vor","delay-in-days":11701,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1972,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Differentiating mitral cells were followed in serial section analysis of mouse embryos from day 12 of gestation (E12) to E14. Animals at E11 and E15 were also examined. Olfactory nerve axons reach the presumptive olfactory bulb at E12 and many penetrate deeply into the intermediate (mantle) layer at this time. The first identified young neurons (postmitotic neuroblasts) were also seen at E12. Many had a tangential orientation, and they occurred only in the region where olfactory nerve axons were present. Olfactory nerve axons (and also mitral cell axons formed later) are characterized by numerous longitudinallyoriented microtubules and an extensive system of transversely and longitudinallyorinted cisternae of smooth endoplasmic reticulum (SER). Near the growing tips of olfactory nerve axons, the microtubules disappear and the SER becomes more extensive and irregular.<\/jats:p><jats:p>The four stages of early mitral cell differentiation determined in the companion paper (Hinds, '72) were confirmed by electron microscopic analysis. In the earliest cells of the primitive radial stage few organelles occur in the perikaryon, but in later cells of this stage and in cells of the pre\u2010axonic tangential stage a Golgi complex and a pair of centrioles occurs on one side of the nucleus at the base of the largest tangential process, thus determining a cell polarity within the tangential plane. This initial polarity at E12 seems to be random and unrelated to the polarity attained when axon outgrowth occurs at E13 and E14, suggesting a re\u2010orientation prior to axon outgrowth. The growing tips of primitive tangential processes were studied and compared with those of growing primitive radial processes and growing axons.<\/jats:p>","DOI":"10.1002\/cne.901460208","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T19:46:57Z","timestamp":1104263217000},"page":"253-276","source":"Crossref","is-referenced-by-count":125,"title":["Early neuron differentiation in the mouse olfactory bulb. II. Electron microscopy"],"prefix":"10.1002","volume":"146","author":[{"given":"James W.","family":"Hinds","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(69)90015-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470715369.ch15"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.65.4.905"},{"key":"e_1_2_1_5_1","first-page":"241a","article-title":"Fine structure of growth cones from cultured sympathetic neurons","volume":"47","author":"Bunge M. B.","year":"1970","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900260203"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401640210"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(70)90169-7"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF01027717","article-title":"Organisation scalariforme du reticulum endoplasmique dans certains processes nerveux de l'hypothalamus de Gasterosteus aculeatus L","volume":"106","author":"Follenius E.","year":"1970","journal-title":"Z. Zellforsch."},{"key":"e_1_2_1_10_1","volume-title":"The Formation of Nerve Connections","author":"Gaze R. M.","year":"1970"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1970.0015"},{"key":"e_1_2_1_12_1","first-page":"203","article-title":"M\u00e9chanisme de d\u00e9veloppement du bulbe olfactif","volume":"48","author":"Giroud A.","year":"1965","journal-title":"Arch. Anat. Histol. Embryol."},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1525\/9780520331884-010","volume-title":"Cellular Aspects of Naural Growth and Differentiation","author":"Herndon R. M.","year":"1971"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901460207"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00391127"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/BF02113024","article-title":"Periodisch auftretende Querstruckturen in Nervenfasern des Bulbus olfactorius der Eltrize Phoxinus laevis","volume":"26","author":"Holz A.","year":"1970","journal-title":"Experientia"},{"key":"e_1_2_1_17_1","unstructured":"Horridge G. A.1968Interneurons. Freeman London pp.312\u2013313."},{"key":"e_1_2_1_18_1","first-page":"150","article-title":"The growth of embryonic neurites. A study on cutures of chick neural tissue","volume":"91","author":"Hughes A. F.","year":"1953","journal-title":"J. Anat. (London)"},{"key":"e_1_2_1_19_1","first-page":"103","article-title":"Regeneration of the endbrain in postmetamorphic Xenopus laevis","volume":"6","author":"Jordan M.","year":"1958","journal-title":"Folia Biol. (Krakow)"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00391129"},{"key":"e_1_2_1_21_1","first-page":"315","article-title":"Experimentelle Untesuchung \u00fcber den Einfluss der Regeneration des Nervus olfactorius auf die Vorderhirnregeneration von Amblystoma mexicanum","volume":"7","author":"Kirsche K.","year":"1964","journal-title":"J. Hirnforsch."},{"key":"e_1_2_1_22_1","first-page":"117","article-title":"The influence of the olfactory nerves on the regeneration of the endbrain in Xenopus laevis tadpoles","volume":"6","author":"Kosciuszko H.","year":"1958","journal-title":"Folia Biol. (Krakow)"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400580102"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.14.1.1"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900910204"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/2161133a0"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00522528"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00522529"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.38.1.193"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900750202"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.44.1.125"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900860205"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900940105"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(69)90040-2"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1242\/jcs.7.1.157","article-title":"An electron\u2010microscopic study of the termination of the afferent fibres to the olfactory bulb from the cerebral hemisphere","volume":"7","author":"Price J. L.","year":"1970","journal-title":"J. Cell Sci."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001240108"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.36.1.151"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/aja.1000520102","article-title":"Studies of living nerves. II. Activities of ameboid growth cones, sheath cells, and myelin segments, as revealed by prolonged observation of individual nerve fibers in frog tadpoles","volume":"52","author":"Speiedel C. C.","year":"1933","journal-title":"Am. J. Anat."},{"key":"e_1_2_1_39_1","first-page":"47","volume-title":"Developmental Neurobiology","author":"Tennyson V. M.","year":"1970"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00235903"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.25.2.407"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.49.3.614"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.901460208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.901460208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:19:34Z","timestamp":1699831174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.901460208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,10]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1972,10]]}},"alternative-id":["10.1002\/cne.901460208"],"URL":"https:\/\/doi.org\/10.1002\/cne.901460208","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,10]]}}}