{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T11:18:06Z","timestamp":1725707886572},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":10143,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Whole head fractionated doses of 200 r and 150 r were initiated postnatally in five experimental age groups (birth, 1\u2010week, 2\u2010week, 3\u2010week and 4\u2010week) and continued over a period of 14 or 20 days to prevent reconstitution of the external granular layer. Animals irradiated at birth displayed minor deficits in behavior, which included ataxia, tremor, hypertonus and dysmetria, while animals irradiated at 1\u2010week showed only mild symptoms of hypermetria. All other animals displayed no motor deficits. Animals irradiated at birth had smaller eyes and ears, a reduction in the size of the entire head and were susceptible to seizures. All animals were sacrified at 70 days of age. The cerebellum was found to be reduced in size and weight, the greatest deficit being seen in animals x\u2010irradiated at the very early ages. Newborn condition animals were found to have large compliments of interneurons in the molecular layer, an established internal granular layer, and Purkinje cells were found to have a normal orientation, position, and to be unreduced in number or size. Total granule cell deficits were found to range from 83% at birth to 29% at four weeks. Quantitative changes for the molecular layer, internal granular layer, medullary layer, Purkinje cell to granule cell ratio, and granule cell density, all depicted the greatest changes in the newborn, 1\u2010week and 2\u2010week conditions. This experiment confirmed that the critical period in the development at which damage would result in behavioral abnormalities was from birth to five days, while for neuroanatomical abnormalities, this critical period was from birth to 18 days.<\/jats:p>","DOI":"10.1002\/cne.901710103","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T19:49:27Z","timestamp":1104263367000},"page":"17-37","source":"Crossref","is-referenced-by-count":9,"title":["Effects of low\u2010level X\u2010irradiation on cat cerebella at different postnatal intervals: I. Quantitative evaluation of morphological changes"],"prefix":"10.1002","volume":"171","author":[{"given":"William J.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin W.","family":"Stromberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900210503"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901360303"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901450305"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901450402"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901450403"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901490203"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901490204"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901650104"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901650105"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901650106"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(71)90150-6"},{"key":"e_1_2_1_13_1","unstructured":"Altman J. andW. J.Anderson1971bExperimental modification of cerebellar circuitry during development and its behavioral consequences. First Ann. Meeting Soc. Neuroscien. 13\u20132."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901460305"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901490202"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(71)90274-5"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(67)90133-1"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(68)90035-6"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(68)90019-8"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091630308"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(69)90015-6"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901280404"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/2141098a0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2307\/3573428","article-title":"Cell pyknosis in the cerebellar cortexxs of infant rats following lowlevel x\u2010irradiation","volume":"46","author":"Altman J.","year":"1971","journal-title":"Radia. Res."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(72)90130-8"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901710104"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901710105"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6773(73)80154-3"},{"key":"e_1_2_1_29_1","first-page":"232","article-title":"Postnatal neurogenesis in the cerebellum of the cat and tritiated thymidine autoradiography","volume":"30","author":"Das G. D.","year":"1971","journal-title":"Br. Res."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00519378"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/cne.901440202","article-title":"Studies on the developing cerebellum. II. The ultrastructure of the external granular layer","volume":"144","author":"DelCerro M. P.","year":"1972","journal-title":"J. Comp. Neur."},{"key":"e_1_2_1_32_1","series-title":"Atomic Energy Symposium 17","first-page":"857","volume-title":"Radiation Biology of the Fetal and Juvenile Mammal","author":"De Vellis J.","year":"1969"},{"key":"e_1_2_1_33_1","volume-title":"The Physiology and Pathology of the Cerebellum","author":"Dow R. S.","year":"1958"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00684728"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00310546","article-title":"The enzymehistochemical maturation of the cerebellar cortex of rats after early postnatal x\u2010irradiation","volume":"22","author":"Ebels E. J.","year":"1970","journal-title":"Histochem."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687566"},{"key":"e_1_2_1_37_1","first-page":"553","volume-title":"Reflex development and behavioral organization. In: Developmental Neurobiology","author":"Fox M. W.","year":"1970"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901280206"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.32.2.277"},{"key":"e_1_2_1_40_1","series-title":"Atomic Energy Symposium 17","first-page":"841","volume-title":"Radiation Biology of the Fetal and Juvenile Mammal","author":"Gilmore S. A.","year":"1969"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901280209"},{"key":"e_1_2_1_42_1","first-page":"60","volume-title":"Disorders of the Developing Nervous System","author":"Hicks S. P.","year":"1961"},{"key":"e_1_2_1_43_1","first-page":"196","volume-title":"Advances in Teratology","author":"Hicks S. P.","year":"1966"},{"key":"e_1_2_1_44_1","series-title":"14th Ann. Symp. Biol.","first-page":"246","volume-title":"Fundamental Aspects of Radiosensitivity","author":"Hicks S. P.","year":"1961"},{"key":"e_1_2_1_45_1","first-page":"535","article-title":"Some effects of radiation on structural and behavioral development","volume":"3","author":"Hicks S. P.","year":"1964","journal-title":"Internat'l. J. Neurol."},{"key":"e_1_2_1_46_1","series-title":"Atomic Energy Symposium 17","first-page":"739","volume-title":"Radiation Biology of the Fetal and Juvenile Mammal","author":"Hicks S. P.","year":"1969"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900990110"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(61)90055-3"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(71)90152-1"},{"key":"e_1_2_1_50_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00005072-196901000-00006","article-title":"The effects of gamma irradiation on the postnatal developing canine cerebellar cortex. I. Effects of single sublethal exposures","volume":"28","author":"Phemister R. D.","year":"1969","journal-title":"J. Neuropath. & Exp. Neurol."},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000750203"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901460304"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901470407"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901390407"},{"key":"e_1_2_1_55_1","first-page":"476","volume-title":"Response of the Nervous System to Ionizing Radiation","author":"Schofer R. J.","year":"1964"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901140204"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420020412"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420020412"},{"key":"e_1_2_1_59_1","first-page":"21","volume-title":"Response of the Nervous System to Ionizing Radiation","author":"Yamazaki J. N.","year":"1962"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.901710103","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.901710103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:12:08Z","timestamp":1699837928000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.901710103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["10.1002\/cne.901710103"],"URL":"https:\/\/doi.org\/10.1002\/cne.901710103","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}