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Lurcher shows severe defects in the granule cells and Purkinje cells soon after birth.<\/jats:p><jats:p>A decrease in the generative layers of the external granular layer is soon as early as two days in the lobulus simplex and by six days of age in the uvula. Granule cell death is common before and during granule cell migration, from 2 to 18 days of age. Loss of granule cells is reflected in reduced growth of the molecular and granular layers. Purkinje cell abnormalities appear at three to four days after birth in the form of crowding, failure of nuclear growth, and condensed or lessened cytoplasm. Purkinje cell death is apparent at four to six days of age depending on the region of the cerebellum.<\/jats:p>","DOI":"10.1002\/cne.901730112","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T19:52:34Z","timestamp":1104263554000},"page":"205-217","source":"Crossref","is-referenced-by-count":64,"title":["Cerebellar histogenesis in the lurcher (<i>Lc<\/i>) mutant mouse"],"prefix":"10.1002","volume":"173","author":[{"given":"Dorothy A.","family":"Swisher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris B.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901360303"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901550207"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90548-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(70)90170-3"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.32.2.277"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901280206"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02171154"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(63)90040-X"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197501000-00001"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/00005072-195312040-00008","article-title":"A method for the combined staining of cells and fibers in the nervous system","volume":"12","author":"Kluver H.","year":"1973","journal-title":"J. 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