{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:15:11Z","timestamp":1782166511387,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":10009,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1977,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of the entorhinal, ipsilateral associational, and commissural afferents to the dentate gyrus have been studied autoradiographically, following the injection of small amounts of tritiated proline into the medial and lateral parts of the entorhinal cortex, and into fields CA<jats:sub>3c<\/jats:sub> and CA<jats:sub>4<\/jats:sub> of the hippocampus, ia series of rats, on the third, sixth, and twelfth postnatal days. Clear labeling of the entorhinal afferents was found at the third postnatal day, and from the earliest stage studied the afferents from the two parts of the entorhinal cortex appear to be spatially segregated within the <jats:italic>stratum moleculare<\/jats:italic> of the dentate gyrus: the fibers from the lateral entorhinal are\u00e0 occupying the outermost one\u2010third, or so, of this stratum, while those from the medial entorhinal cortex occupy its middle zone. The ipsilateral hippocampo\u2010dentate associational pathway is present at the third postnatal day, but the commissural projection (which shares wiht it the inner part of the stratum moleculare) could not be labeled until the sixth postnatal day. By the twelfth day the characteristic adult pattern of distribution of the terminals of the two hippocampo\u2010dentate pathways is established. although this pattern is best accounted for on the basis of a temporal competition for the available synaptic sites on the proximal parts of the dendrites of the granule cells, the spatial segregation of these two fiber systems from those arising in the entorhinal cortex, is probably due to the selective fasciculation of fibers in each group of afferents and to their early cytochemical specificity.<\/jats:p>","DOI":"10.1002\/cne.901730203","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T19:51:51Z","timestamp":1104263511000},"page":"231-250","source":"Crossref","is-referenced-by-count":103,"title":["An autoradiographic study of the development of the entorhinal and commissural afferents to the dentate gyrus of the Rat"],"prefix":"10.1002","volume":"173","author":[{"given":"R.","family":"Fricke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. M.","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-85986-1_11"},{"key":"e_1_2_1_3_1","volume-title":"The Use of Axonal Transport for Studies of Neuronal Connectivity","author":"Cowan W. M.","year":"1975"},{"key":"e_1_2_1_3_2","first-page":"1","volume-title":"The Use of Axonal Transport for Studies of Neuronal Connectivity","year":"1974"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90344-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90088-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90930-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-8109-9_4"},{"key":"e_1_2_1_8_1","unstructured":"Fricke R. A.1975Studies of the morphology and development of the hippocampus and dentate gyrus. Doctoral Thesis Washington University St. Louis."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90514-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901490402"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0014-4886(71)90142-7","article-title":"Changes in the rate of axoplasmic transport during the postnatal development of the rabbit's optic nerve and tract","volume":"30","author":"Hendrickson A. E.","year":"1971","journal-title":"Exp. Neur."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901280305"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90604-5"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF00307412","article-title":"Distribution of acetylcholinesterase in the hippocampal region of the rat during postnatal development","volume":"141","author":"Mellgren S. I.","year":"1973","journal-title":"Z. Zellforsch."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00339754"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901590202"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.50.4.703"},{"key":"e_1_2_1_18_1","first-page":"1190","article-title":"The organization of afferents to the dentate gyrus of the hippocampal formation in the reeler mutant mouse","volume":"1","author":"Stanfield B. 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