{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:07:32Z","timestamp":1760980052233},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":9778,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Earlier small\u2010angle X\u2010ray diffraction studies have indicated that central and peripheral nerve myelins may be significantly different structurally, although relatively few examples for each system and for individual species have been examined. In order tounderstand better the intra\u2010 and inter\u2010system relationships, this study has developed more extensive information for a single species: six cases centrally and ten peripherally, featuring cranial nerves and a few others of the human nervous system. Peripheral myelin spacings (membrane pair thicknesses) are relatively similar, 184.4 \u00b1 1.40 \u00c5, and the ratios of diffraction peak height intensities of the second to fourth orders are also closelybunched: 1.85 \u00b1 0.216. Central myelin spacings and intensity ratios are distinctly different and more variable: spacings 160.3\u2010165.8 A and intensity ratios 2.81\u20104.46. It appears that within a given species or between closely related (e.g., mammalian) species peripheral myelins possess relatively invariant structures, though significant spacing declines are encountered for both systems as phylogenetic relationships become more distant. The observed greater variability of CNS structures within a singlespecies may correspond to known compositional differences between CNS regionsor result from observational difficulties. In any case there is a marked discontinuity between the myelin structures of CNS and PNS nerves.<\/jats:p>","DOI":"10.1002\/cne.901770102","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T18:20:37Z","timestamp":1104603637000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["An X\u2010ray diffraction comparison of myelins from the human nervous system"],"prefix":"10.1002","volume":"177","author":[{"given":"Ronald J.","family":"Chandross","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard S.","family":"Bear","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Royce L.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1962.tb11857.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(71)90082-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(69)90006-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/newbio231046a0","article-title":"Myelin membrane structure at 10 \u00c5 resolution","volume":"231","author":"Caspar D. L. D.","year":"1971","journal-title":"Nature New Biol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/cne.901770103","article-title":"Discontinuous transition of myelin structure at the junction between central and peripheral components of the eighth cranial nerve, as disclosed by x\u2010ray diffraction","volume":"177","author":"Chandross R. J.","year":"1977","journal-title":"J. Comp. Neur."},{"key":"e_1_2_1_7_1","first-page":"469","article-title":"The lipid composition of rat brain myelin and subcellular fractions during development","volume":"12","author":"Cuzner M. L.","year":"1968","journal-title":"J. Neurochem."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(69)90237-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02531734"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.3.5.725"},{"key":"e_1_2_1_11_1","unstructured":"Finean J. B.1953Structural features of lipid and lipoprotein complexes in nerve myelin. International Colloquium on Biochemical Problems of Lipids Brussels p.82."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(63)80115-1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb00089.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1748-1716.1961.tb02139.x","article-title":"X\u2010ray diffraction studies on peripheral nerve myelin","volume":"51","author":"H\u00f6lund G.","year":"1961","journal-title":"Acta Physiol. Scand."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1968.tb08945.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(75)90142-4"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1974.tb04409.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(76)80149-0"},{"key":"e_1_2_1_19_1","first-page":"507","article-title":"Myelin: a report based on an NRP work session","volume":"9","author":"Mokrasch L. C.","year":"1971","journal-title":"Neurosci. Res. 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