{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:51:38Z","timestamp":1771627898263,"version":"3.50.1"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"vor","delay-in-days":9770,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1978,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Elecrophysiological recordings were made from superficial parts of the spinal dorsal horn in monkeys, using dye\u2010filled micropipette electrodes to permit iontophoretic marking of the recording sites for subsequent histological recovery. Focal field potentials and unitary activity evoked by dorsal root volleys including slowly\u2010conducting components (both myelinated and unmyelinated) were found in the posteromarginal zone and the substantia gelatinosa (SG). Unitary potentials identified as being of the type recorded from cellular regions wee separated into categories according to which groups of slowly\u2010conducting fibers and which kinds of cutaneous stimulation evoked the discharge. Recording locations for units exicted by volleys in myelinated fibers conducting under 35 m\/sec, by the types of skin stimulation activating either highthreshold mechanoreceptors (nociceptos) or cooling thermoreceptors, and giving no evidence of suprathreshold C\u2010fiber excitation were centered on the posteromarginal zone. In conrast, recording loci for units exhibiting a strong C\u2010fiber excitation and responses to cutaneous stimulation known to effectively excite C\u2010fiber polymodal nociceptors or C\u2010mechanoreceptors were centered in the SG. There appeared varying degrees of convergence of primary afferent input to the neuronal units, although most showed substantial specificity in their afferent excitation. On the bases of these esults and consideration of existing morphological daa, it is proposed that the marginal zone is a major synaptic termination region for the affeent fibers from high\u2010threshold mechanoreceptors, cooling thermoreceptors, and perhaps otehr receptors with fine myelinated peripheral fibers. The SG, on the other hand, is suggested to be the terminal region for all types of unmyelinated primary afferent sensory neurons, and to have the complex role of integrating and distributing this input.<\/jats:p>","DOI":"10.1002\/cne.901770305","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T18:20:37Z","timestamp":1104603637000},"page":"417-434","source":"Crossref","is-referenced-by-count":267,"title":["Excitation of marginal and substantia gelatinosa neurons in the primate spinal cord: Indications of their place in dorsal horn functional organization"],"prefix":"10.1002","volume":"177","author":[{"given":"T.","family":"Kumazawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. R.","family":"Perl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"126","article-title":"Ueber die hinteren Nervenwurzeln, ihre Endigung in der grauen Substanz des R\u00fcckenmarkes und ihre centrale Fortsetzung im letzteen","volume":"11","author":"Bechterew W.","year":"1887","journal-title":"Arch. Anat. Physiol., Anat. Abt."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1976.39.6.1160"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1971.34.1.116"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1969.32.6.1025"},{"key":"e_1_2_1_6_1","first-page":"478","volume-title":"Handbuch der mikroskopischen Anatomie des Menschen","author":"Bok S. T.","year":"1928"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00239031"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(74)90080-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00235027"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1967.sp008227"},{"key":"e_1_2_1_11_1","first-page":"29","volume-title":"Handbook of Sensory Physiology. Vol. 2, somatosensory System","author":"Burgess P. R.","year":"1973"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1968.31.6.833"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(76)90042-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1970.33.2.293"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1952.tb00916.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900960104"},{"key":"e_1_2_1_17_1","first-page":"121","article-title":"\u00dcber die Fortsetzung der hinteren R\u00fcckenmarkswurzeln zum Gehirn","volume":"4","author":"Edinger L.","year":"1889","journal-title":"Anat. Anz."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02870563"},{"key":"e_1_2_1_19_1","first-page":"79","volume-title":"Handbook of Sensory Physiology. Vol. 2, Somatosensory System","author":"Hensel H.","year":"1973"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00586896"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(76)90008-7"},{"key":"e_1_2_1_22_1","first-page":"579","article-title":"Histochemical analysis of peptide pathways possibly related to pain and analgesia: substance P, enkephalin and somatostatin","volume":"12","author":"H\u00f6kfelt T.","year":"1977","journal-title":"Proc. Intl. Union Physiol. Sci."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1959.sp006248"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1959.sp006249"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01232999"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008701"},{"key":"e_1_2_1_27_1","first-page":"466","article-title":"The phylogenetic development of the substantia gelatinosa Rolandi, Koningl. Akad. Wetenschap. Amsterdam","volume":"32","author":"Keenan E.","year":"1929","journal-title":"Proc. Sect. Sci."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(75)90072-X"},{"key":"e_1_2_1_29_1","series-title":"Wenner\u2010Gren Center Intl. Symp. Series","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/B978-0-08-021208-1.50011-4","volume-title":"Sensory Functions of the Skin in Primates","author":"Kumazawa T.","year":"1976"},{"key":"e_1_2_1_30_1","first-page":"305","article-title":"Primate cutaneous receptors with unmyelinated (C) fibres and their projection to the substantia gelatinosa","volume":"73","author":"Kumazawa T.","year":"1977","journal-title":"J. Physio. (Paris)"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1977.40.6.1325"},{"key":"e_1_2_1_32_1","first-page":"328","article-title":"Excitation of Posteromarginal cells (lamina I) in monkey and their projection in lateral spinal tracts","volume":"9","author":"Kumazawa T.","year":"1971","journal-title":"Proc. Intl. Union Physiol. Sci."},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901620102"},{"key":"e_1_2_1_34_1","first-page":"675","volume-title":"Sensory Paths in the Spinal Cord and Brain Stem of Man","author":"Kuru M.","year":"1949"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901720308"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.128.3326.712"},{"key":"e_1_2_1_37_1","volume-title":"Pain","author":"Lewis T.","year":"1942"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172697"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90110-8"},{"key":"e_1_2_1_40_1","first-page":"11","volume-title":"Pain","author":"Mehler W. R.","year":"1966"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb20460.x"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3699.971"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1964.sp007417"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/206097a0"},{"key":"e_1_2_1_45_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3181\/00379727-30-6461","article-title":"Dorsal root fibers which contribute to the tract of Lissauer","volume":"30","author":"O'Leary J. L.","year":"1932","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"e_1_2_1_46_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1001\/archneurpsyc.1952.02320220092011","article-title":"Role of gelatinous substance of spinal cord in conduction of pain","volume":"68","author":"Pearson A. A.","year":"1952","journal-title":"Arch. Neurol. & Psychiat."},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1968.sp008576"},{"key":"e_1_2_1_48_1","first-page":"1141","volume-title":"Biology Data Book","author":"Perl E. R.","year":"1973"},{"key":"e_1_2_1_49_1","first-page":"263","volume-title":"Progress in Brain Research. Vol. 43, Somatosensory and Visceral Receptor Mechanisms","author":"Perl E. R.","year":"1976"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02138738"},{"key":"e_1_2_1_51_1","doi-asserted-by":"crossref","DOI":"10.5962\/bhl.title.48637","volume-title":"Histologie du Syst\u00e8me Nerveux de \u013eHomme et des Vert\u00e9br\u00e9s","author":"Ram\u00f3n y Cajal S.","year":"1909"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000160104"},{"key":"e_1_2_1_53_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/ajplegacy.1916.40.4.571","article-title":"The conduction of painful afferent impulses in the spinal nerves","volume":"40","author":"Ranson S. W.","year":"1916","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_54_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1152\/ajplegacy.1915.38.1.128","article-title":"The conduction within the spinal cord of the afferent impulses producing pain and the vasomotor reflexes","volume":"38","author":"Ranson S. W.","year":"1915","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901720307"},{"key":"e_1_2_1_56_1","first-page":"207","volume-title":"Handbook of Sensory Physiology. Vol. 2, Somatosensory System","author":"R\u00e9thelyi M.","year":"1973"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(68)90256-4"},{"key":"e_1_2_1_58_1","first-page":"485","article-title":"The organization of dorsal root fibers at entry into the spinal cord of the cat","volume":"181","author":"Snyder R. L.","year":"1975","journal-title":"Anat. Rec."},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901740104"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901220207"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90518-1"},{"key":"e_1_2_1_62_1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1152\/jn.1973.36.4.750","article-title":"Location of cells of origin of spinothalamic tract in lumbar enlargemen of the monkey","volume":"36","author":"Trevino D. L.","year":"1973","journal-title":"J. Neurophysiol"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1962.sp007034"},{"key":"e_1_2_1_64_1","first-page":"92","volume-title":"Progress in Brain Research. Vol. 12, Physiology of Spinal Neurons","author":"Wall P. D.","year":"1964"},{"key":"e_1_2_1_65_1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1152\/jn.1974.37.2.358","article-title":"Responses of primate spinothalamic tract neurons to natural stimulation of hindlimb","volume":"37","author":"Willis W. D.","year":"1974","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_66_1","first-page":"1","article-title":"Studies in the peripheral nervous mechanism of pain","volume":"80","author":"Zotterman Y.","year":"1933","journal-title":"Acta Med. Scand."}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.901770305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.901770305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:15:10Z","timestamp":1699838110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.901770305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,2]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,2]]}},"alternative-id":["10.1002\/cne.901770305"],"URL":"https:\/\/doi.org\/10.1002\/cne.901770305","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,2]]}}}