{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:15:12Z","timestamp":1791281712089,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":9109,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1979,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Immunohistochemical methods have been used to describe the distribution of neurophysin I\u2010 and oxytocin\u2010stained fibers in the spinal cord. In albino rats of either sex, such fibers descend through the dorsal part of the lateral funiculus to the caudal end of the cord. Fibers leave the lateral funiculus to innervate the marginal zone of the dorsal horn at all levels, and the intermediolateral column at thoracic, lumbar and sacral levels. Some fibers course medially through the intermediate gray to end in the central gray, which is innervated at all levels, and also appears to be innervated by fibers descending in the central gray itself. A semiquantitative analysis shows that the density of terminal fields in the intermediolateral column, marginal zone, and central gray varies significantly at different levels. The intermediolateral column is preferentially innervated between T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010T\n                    <jats:sub>3<\/jats:sub>\n                    , T\n                    <jats:sub>9<\/jats:sub>\n                    \u2010T\n                    <jats:sub>11<\/jats:sub>\n                    , and T\n                    <jats:sub>13<\/jats:sub>\n                    \u2010L\n                    <jats:sub>2<\/jats:sub>\n                    . The nucleus intercalatus spinalis and the dorsal commissural nucleus (between T\n                    <jats:sub>13<\/jats:sub>\n                    and L\n                    <jats:sub>2<\/jats:sub>\n                    ), both of which contain preganglionic neurons, are densely innervated.\n                  <\/jats:p>\n                  <jats:p>\n                    In the monkey (\n                    <jats:italic>Macaca fascicularis<\/jats:italic>\n                    ), neurophysin I\u2010 and oxytocin\u2010stained fibers descend through the lateral funiculus to the filum terminale, where some of them enter the pia\u2010arachnoid surrounding the filum. The intermediolateral column is not innervated between T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010T\n                    <jats:sub>3<\/jats:sub>\n                    , is sparsely innervated at sacral levels, and is moderately innervated between T\n                    <jats:sub>4<\/jats:sub>\n                    and L\n                    <jats:sub>3<\/jats:sub>\n                    ; the greatest density of fibers occurs at L\n                    <jats:sub>3<\/jats:sub>\n                    . At most levels, few if any fibers are found in the central gray and marginal zone; the central gray is sparsely innervated between T\n                    <jats:sub>8<\/jats:sub>\n                    and L\n                    <jats:sub>2<\/jats:sub>\n                    , at S\n                    <jats:sub>2<\/jats:sub>\n                    , and between Co\n                    <jats:sub>3<\/jats:sub>\n                    \u2010Co\n                    <jats:sub>6<\/jats:sub>\n                    , and the marginal zone contains a small number of fibers in the region of S\n                    <jats:sub>2<\/jats:sub>\n                    and Co\n                    <jats:sub>6<\/jats:sub>\n                    .\n                  <\/jats:p>\n                  <jats:p>Neurophysin I\u2010 and oxytocin\u2010stained fibers were also found in the intermediolateral column, marginal zone, and central gray of homozygous Brattleboro, spontaneously hypertensive, and Egyptian sand rats.<\/jats:p>\n                  <jats:p>The results suggest that the paraventriculo\u2010spinal pathway is particularly related to specific groups of sympathetic and parasympathetic preganglionic neurons, and to the marginal zone, which is involved in the relay of ascending nociceptive information through the spinothalamic tract.<\/jats:p>","DOI":"10.1002\/cne.901880108","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:31:52Z","timestamp":1104586312000},"page":"87-106","source":"Crossref","is-referenced-by-count":299,"title":["The distribution of oxytocin\u2010 and neurophysin\u2010stained fibers in the spinal cord of the rat and monkey"],"prefix":"10.1002","volume":"188","author":[{"given":"L. W.","family":"Swanson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"McKellar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF00319746","article-title":"Nature and distribution of neurosecretory cells of the reptilian brain","volume":"43","author":"Ananthanrazanan V.","year":"1955","journal-title":"Z. Zellforsch."},{"key":"e_1_2_1_3_1","first-page":"126","article-title":"De l'existence de voies neuros\u00e9cr\u00e9toires hypothalamo\u2010t\u00e9lenc\u00e9phalique chez la chauve souris (Rhinolophus ferrum equinum) en \u00e9tat d'hibernation","volume":"13","author":"Barry J.","year":"1954","journal-title":"Bull. Soc. Sci. Nancy"},{"key":"e_1_2_1_4_1","first-page":"264","article-title":"Les voies extra\u2010hypophysaires de la neuros\u00e9cr\u00e9tion diencephalique","volume":"89","author":"Barry J.","year":"1956","journal-title":"Bull. Ass. Anat."},{"key":"e_1_2_1_5_1","first-page":"3","article-title":"Recherches morphlogiques et exp\u00e9rimentales sur la glande diencephalique et l'appariel hypothalamo\u2010hypophysaire","volume":"2","author":"Barry J.","year":"1961","journal-title":"Ann. Sci. Univ. Besancon. Zool. Physiol. Sci."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90068-3"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1930.0027"},{"key":"e_1_2_1_8_1","first-page":"83","article-title":"A study of factors controlling activity of neurons within the paraventricular, supraoptic and ventromedian nuclei of the hypothalamus","volume":"16","author":"McC. Brooks C.","year":"1966","journal-title":"Acta Physiol. Latinoam."},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00224932","article-title":"Intra\u2010 and extrahypothalamic vasopressin and oxytocin pathways in the rat. Pathways to the limbic system, medulla oblonga and spinal cord","volume":"192","author":"Buijs R. M.","year":"1978","journal-title":"Cell Tiss. Res."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901780102"},{"key":"e_1_2_1_11_1","first-page":"18","article-title":"Paraventricular and supraoptic hypothalamic nuclei: What are their roles in central regulation of heart rate?","volume":"4","author":"Ciriello J.","year":"1978","journal-title":"Soc. Neurosci. Abs."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901690206"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00215873"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122702"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90161-0"},{"key":"e_1_2_1_16_1","first-page":"91","article-title":"Degeneration in the hypothalamic connexions of the albino rat","volume":"91","author":"Guillery R.","year":"1957","journal-title":"J. Anat."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(76)90070-7"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901830106"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/21.4.312"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901440205"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00525371"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90378-X"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.47.4.691"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90790-2"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009776"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012575"},{"key":"e_1_2_1_27_1","volume-title":"The Autonomic Nervous System","author":"Kuntz A.","year":"1947"},{"key":"e_1_2_1_28_1","first-page":"996","article-title":"Les voies eff\u00e9rentes des noyaux neuros\u00e9cr\u00e9toires hypothalamiques chez les oiseaux","volume":"150","author":"Legait H.","year":"1956","journal-title":"C.R. Soc. Biol."},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1159\/000141221","article-title":"Les voies extra\u2010hypophysoires des noyaux neuros\u00e9cr\u00e9toires hypothalamiques chez les batraciens et les reptiles","volume":"30","author":"Legait H.","year":"1957","journal-title":"Acta Anat."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901790304"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1113\/jphysiol.1975.sp011064","article-title":"Factors governing the periodic activation of supraoptic and paraventricular neurosecretory cells during suckling in the rat","volume":"250","author":"Lincoln D. W.","year":"1975","journal-title":"J. Physiol. (London)"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90056-2"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/81.3.319"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0590559"},{"key":"e_1_2_1_35_1","first-page":"351","article-title":"Oxytocin\u2010neurophysin pathways to the lower brainstem and spinal cord of the rat","volume":"4","author":"Nilaver G.","year":"1978","journal-title":"Soc. Neurosci. Abs."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011683"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90707-7"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(78)90025-3"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901460205"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90160-9"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901000205"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1992.tb02935.x"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90738-1"},{"key":"e_1_2_1_44_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2307\/1538506","article-title":"Neurosecretion. A relationship between the paraphysis and the paraventricular nucleus in the garter snake (Thamnophis sp.)","volume":"1","author":"Scharrer E.","year":"1951","journal-title":"Biol. Bull."},{"key":"e_1_2_1_45_1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/0014-4886(75)90107-7","article-title":"Preganglionic innervation of the adrenal gland of the rat. A study using horseradish peroxidase","volume":"49","author":"Schramm L. P.","year":"1975","journal-title":"Exp. Neur."},{"key":"e_1_2_1_46_1","first-page":"34","volume-title":"Nervous Control of the Heart","author":"Smith O. A.","year":"1965"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-12587-8_5"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)91000-9"},{"key":"e_1_2_1_49_1","first-page":"415","article-title":"Extra\u2010hypophysial oxytocin\u2010containing pathways in the brain and spinal cord of the rat and monkey","volume":"4","author":"Swanson L. W.","year":"1978","journal-title":"Soc. Neurosci. Abst."},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901600102"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901860408"},{"key":"e_1_2_1_52_1","unstructured":"Swanson L. W. andB. K.Hartman1979Biochemical specificity in central pathways related to peripheral and intracerebral homeostatic functions. Neurosci. Let. in press."},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00222435"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00221802"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1947.0037"},{"key":"e_1_2_1_56_1","first-page":"585","article-title":"Vasopressin content and neurosecretory material in the hypothalamo\u2010neurohypophysial system of rats under different states of water metabolism","volume":"63","author":"Vilhardt L. H.","year":"1970","journal-title":"Acta Endocrinol."},{"key":"e_1_2_1_57_1","first-page":"1","article-title":"Zur topographic der Medulla spinalis der Albinoratte (Rattus norvegicus)","volume":"47","author":"Waibl H.","year":"1973","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/258082a0"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900710305"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.901880108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.901880108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:18:52Z","timestamp":1699827532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.901880108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,11]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,11]]}},"alternative-id":["10.1002\/cne.901880108"],"URL":"https:\/\/doi.org\/10.1002\/cne.901880108","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,11]]}}}