{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:36:11Z","timestamp":1771630571400,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":8957,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1980,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of the indolic neurotoxins 5,6\u2010 and 5,7\u2010dihydroxytryptamine (5,6\u2010DHT; 5,7\u2010DHT) on the enteric nervous system were examined. 5,6\u2010DHT, in moderate dosage, 40 mg\/kg, decreased uptake of tritiated 5\u2010hydroxytryptamine (<jats:sup>3<\/jats:sup>H\u20105\u2010HT) but not that of tritiated norepinephrine (<jats:sup>3<\/jats:sup>H\u2010NE). However, selectivity of the neurotoxins for enteric serotonergic rather than adrenergic axons was enhanced by pretreating animals with desmethylimipramine to inhibit the catecholamine uptake mechanism. When this was done, 5,7\u2010DHT was found to prevent the development of 5\u2010HT histofluorescence (following injection of L\u2010tryptophan) without affecting histofluorescence of NE. In contrast, 6\u2010hydroxydopamine virtually abolished NE histofluorescence and uptake of <jats:sup>3<\/jats:sup>H\u2010NE without affecting development of 5\u2010HT histofluorescence or uptake of <jats:sup>3<\/jats:sup>H\u20105\u2010HT. Electron microscopy revealed that 5,7\u2010DHT induced dose\u2010dependent lesions of axonal varicosities in the enteric nervous system. Early lesions, 1\u20134 hours following injection, resembled cytolysosomes and consisted of membrane enclosed regions of opaque cytoplasm containing synaptic vesicles. Affected varicosities contained a mixed population of large dense cored (\u223c120nm) and small lucent vesicles (\u223c70nm) but none exhibited pre\u2010 or postsynaptic membrane specializations. After 24 hours terminals degenerated and were engulfed by surrounding supporting cells. It is concluded that peripheral serotonergic neurons resemble central serotonergic neurons in susceptibility to the toxic effects of indolic neurotoxins. These neurotoxins are useful anatomical markers of serotonergic terminal varicosities.<\/jats:p>","DOI":"10.1002\/cne.901900311","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T23:14:54Z","timestamp":1104621294000},"page":"581-596","source":"Crossref","is-referenced-by-count":27,"title":["Effects of indolic neurotoxins on enteric serotonergic neurons"],"prefix":"10.1002","volume":"190","author":[{"given":"Michael D.","family":"Gershon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane L.","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl F.","family":"Dreyfus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.172.3988.1159"},{"key":"e_1_2_1_3_1","first-page":"1","article-title":"Evaluation of the effects of 5,7\u2010dihydroxytryptamine on serotonin and catecholamine neurons in the rat CNS","volume":"391","author":"Baumgarten H. 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