{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:30:34Z","timestamp":1789965034858,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":8420,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1981,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was done to determine whether a pathway of efferent axons in the carotid sinus nerve is necessary for the phenomenon of \u201cefferent inhibition\u201d (inhibition induced in carotid body chemoreceptors by electrical stimulation of the carotid sinus nerve). Our approach was to eliminate efferent axons in the carotid sinus nerve of cats without destroying the sensory axons. This was achieved by cutting the ipsilateral glossopharyngeal and vagus nerves central to their sensory ganglia and\/or by removing the nodose and superior cervical ganglia. In neurophysiological studies we found that the response of chemoreceptors in cats 10 days after surgery was the same as that in controls. Chemoreceptor activity was decreased by electrical stimulation of the carotid sinus nerve and was increased by hypoxia and cyanide. In operated cats as in control animals, \u201cefferent inhibition\u201d was abolished by haloperidol and dihydroergotamine, drugs that block the inhibitory action of dopamine. Electron microscopic studies disclosed that the number of nerve endings in glomus cell\/sheath cell complexes was not measurably different in control and experimental carotid bodies. By contrast, 10 days after the carotid sinus nerve was cut the number of nerve endings next to such cells was reduced by more than 99%. Cutting the nerve roots and excising the ganglia eliminated most nerve endings on blood vessels: The number of noradrenergictype nerve endings was reduced by 99% and other types of nerve endings (presumptive cholinergic and peptidergic types) were reduced by more than 90%. Our experiments indicate that \u201cefferent inhibition\u201d is not abolished by operations that destroy inputs to blood vessels and to carotid body glomus cells from (1) the nodose ganglion, (2) superior cervical ganglion, or from (3) neurons in the brain stem whose axons run in the glossopharyngeal or vagus nerves. We conclude that \u201cefferent inhibition\u201d may be caused by antidromic stimulation of sensory axons.<\/jats:p>","DOI":"10.1002\/cne.902010310","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T20:22:34Z","timestamp":1117225354000},"page":"457-476","source":"Crossref","is-referenced-by-count":42,"title":["The neural pathway involved in \u201cefferent inhibition\u201d of chemoreceptors in the cat carotid body"],"prefix":"10.1002","volume":"201","author":[{"given":"Donald M.","family":"McDonald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901840208"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1152\/jn.1974.37.6.1131","article-title":"Efferent influences on carotid body chemoreceptors","volume":"37","author":"Belmonte C.","year":"1974","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90276-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1971.51.3.437"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/216294a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1968.sp008510"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.30.3.563"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1967.sp001882"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1970.sp009110"},{"key":"e_1_2_1_11_1","first-page":"509","article-title":"Purinergic nerves","volume":"24","author":"Burnstock G.","year":"1972","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_1_12_1","first-page":"365","article-title":"Sur la structure et l'innervation de la glande intercarotidienne (glomus caroticum) de l'homme et des mammiferes, et sur un nouveau syst\u00e8me d'innervation autonome du nerf glossopharyngien","volume":"24","author":"de Castro F. S.","year":"1926","journal-title":"Trab. Lab. Invest. Biol. Univ. Madrid"},{"key":"e_1_2_1_13_1","first-page":"330","article-title":"Sur la structure et l'innervation du sinus carotidien de l'homme et des mammiferes. Nouveaux faits sur l'innervation et al fonction du glomus caroticum","volume":"25","author":"de Castro F.","year":"1928","journal-title":"Trav. Lab. Invest. Biol. Univ. Madrid"},{"key":"e_1_2_1_14_1","first-page":"267","volume-title":"Arterial Chemoreceptors","author":"de Castro F.","year":"1968"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.472721"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012354"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(70)90003-X"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480060407"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1973.sp010189"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90106-7"},{"key":"e_1_2_1_21_1","first-page":"387","article-title":"Electron microscopy of sympathetic tissues","volume":"18","author":"Grillo M. A.","year":"1966","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_1_22_1","first-page":"1365","article-title":"Innervation of the cat carotid body: Normal and experimental studies","volume":"31","author":"Hess A.","year":"1972","journal-title":"Fed. Proc."},{"key":"e_1_2_1_23_1","first-page":"1","article-title":"Coexistence of peptides and putative transmitters in neurons","volume":"22","author":"H\u00f6kfelt T.","year":"1980","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1152\/jappl.1980.49.1.45","article-title":"Interaction of dopamine and haloperidol with O2 and CO2 chemoreception in carotid body","volume":"49","author":"Lahiri S.","year":"1980","journal-title":"J. Appl. Physiol.: Respirat. Environ. Exercise Physiol."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00489676"},{"key":"e_1_2_1_26_1","first-page":"403","article-title":"Activit\u00e9 eff\u00e9rente d'origine centrale dans le nerf sino\u2010carotidien du Lapin","volume":"61","author":"Laurent P.","year":"1969","journal-title":"J. Physiol. (Paris)"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1979.tb06475.x"},{"key":"e_1_2_1_28_1","first-page":"25","article-title":"Peripheral peptide neurons: Distribution, axonal transport, and some aspects on possible function","volume":"22","author":"Lundberg J. M.","year":"1980","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"e_1_2_1_29_1","first-page":"58P","article-title":"Sinus nerve efferent activity survives suprapetrosal section","volume":"295","author":"McAllen R. M.","year":"1979","journal-title":"J. Physiol. (Lond.)"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(75)90050-X"},{"key":"e_1_2_1_31_1","first-page":"2627","article-title":"Regulation of chemoreceptor sensitivity in the carotid body: The role of presynaptic sensory nerves","volume":"39","author":"McDonald D. M.","year":"1980","journal-title":"Fed. Proc."},{"key":"e_1_2_1_32_1","first-page":"105","volume-title":"Respiratory Control and Clinical Applications (Vol. 17 (Part I) of: Lung Biology in Health and Disease)","author":"McDonald D. M.","year":"1981"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01098781"},{"key":"e_1_2_1_34_1","first-page":"2662","article-title":"Carotid sinus nerve efferents: Properties and physiological significance","volume":"39","author":"Majcherczyk S.","year":"1980","journal-title":"Fed. Proc."},{"key":"e_1_2_1_35_1","first-page":"269","volume-title":"The Peripheral Arterial Chemoreceptors","author":"Mitchell R. A.","year":"1975"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(69)80029-8"},{"key":"e_1_2_1_37_1","first-page":"69P","article-title":"Effects of sinus and aortic nerve efferents on arterial chemoreceptor function","volume":"200","author":"Neil E.","year":"1969","journal-title":"J. Physiol. (Lond.)"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009455"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009456"},{"key":"e_1_2_1_40_1","first-page":"303","article-title":"The ultrastructure and source of nerve endings in the carotid body","volume":"154","author":"Neil K.","year":"1974","journal-title":"Cell Tissue Res."},{"key":"e_1_2_1_41_1","first-page":"724","volume-title":"Histologie du Syst\u00e8me Nerveux de l'Homme et des Vert\u00e9br\u00e9s, Tome I","author":"Ram\u00f3n y Cajal S.","year":"1972"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90236-3"},{"key":"e_1_2_1_43_1","first-page":"207","volume-title":"The Peripheral Arterial Chemoreceptors","author":"Sampson S. R.","year":"1975"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01900082"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90818-5"},{"key":"e_1_2_1_46_1","first-page":"119","article-title":"A pharmacological analysis of neurally induced inhibition of carotid body chemoreceptor activity in cats","volume":"197","author":"Sampson S. R.","year":"1976","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_47_1","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1152\/ajplegacy.1976.230.6.1494","article-title":"Analysis of inhibitory effect of dopamine on carotid body chemoreceptors in cats","volume":"230","author":"Sampson S. R.","year":"1976","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_48_1","first-page":"127","volume-title":"Nonparametric Statistics for the Behavioral Sciences","author":"Siegel S.","year":"1956"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90016-0"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90861-7"},{"key":"e_1_2_1_51_1","first-page":"229","article-title":"Untersuchungen zur Frage eines cholinergischen Gliedes in der postganglion\u00e4ren sympathischen Transmission","volume":"24","author":"Thoenen H.","year":"1966","journal-title":"Helv. Physiol. Pharmacol. Acta"},{"key":"e_1_2_1_52_1","first-page":"40P","article-title":"Enkephalin\u2010, vasoactive intestinal polypeptide\u2010 and substance P\u2010like immunoreactivity in the cat carotid body","volume":"85","author":"Wharton J.","year":"1980","journal-title":"J. Endocrinol."},{"key":"e_1_2_1_53_1","first-page":"253","volume-title":"The Peripheral Arterial Chemoreceptors","author":"Willshaw P.","year":"1975"},{"key":"e_1_2_1_54_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/978-3-642-66755-8_24","volume-title":"Chemoreceptors in the Carotid Body","author":"Willshaw P.","year":"1977"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-4009-6_30"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.46.3.544"},{"key":"e_1_2_1_57_1","first-page":"291","article-title":"Modulatory role of dopamine on arterial chemoreceptors","volume":"16","author":"Zapata P.","year":"1977","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(80)90006-7"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902010310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902010310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:03:27Z","timestamp":1699841007000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902010310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9,20]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,9,20]]}},"alternative-id":["10.1002\/cne.902010310"],"URL":"https:\/\/doi.org\/10.1002\/cne.902010310","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,9,20]]}}}