{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:31:26Z","timestamp":1762075886784},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":8378,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1981,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of a moderately severe monaural conductive hearing loss on the development of neuronal size in the avian nucleus magnocellularis (NM) was investigated. NM is considered to be the homologue of the mammalian anteroventral cochlear nucleus and receives large calyceal synaptic endings from the cochlear nerve. Silicone plastic earplugs which produce a 40 dB broadband conductive hearing loss were placed in one external auditory canal of chick embryos on the 18th day of incubation. After hatching, all animals were housed in communal brooders and sacrificed at 4, 10, 25, and 60 days of age. Nissl\u2010stained sections from paraffin\u2010 and plastic\u2010embedded brains were used to sample neuronal cross\u2010sectional areas in NM on the deprived and nondeprived sides of the brain. These samples were obtained separately in each brain from three posterior\u2010to\u2010anterior percentage quartiles within NM. Statistical analyses of these data showed that the severity of deprivation\u2010induced cell size changes in NM varied as a function of both age and position. In the 4\u2010 and 10\u2010day groups, no significant deprived\u2010versus\u2010nondeprived differences in neuronal size were seen in any area of the nucleus. At 25 days after hatching, only the third posterior\u2010to\u2010anterior quartile (i.e., 50\u201374%) showed a significant difference; this difference was also significantly greater than those in the second and fourth quartiles at this age. By 60 days, all three sampled areas in NM showed highly significant differences (averaging 12%) in mean neuronal cross\u2010sectional area. Cell size values from the deprived and nondeprived sides of 60\u2010day\u2010old experimental animals were also compared with values from 60\u2010day\u2010old control subjects. Whereas the deprived NM cells were significantly smaller than controls, there was no evidence for a reliable hypertrophy in the nondeprived cells. Thus, the principal effect of the acoustic deprivation produced was to retard continued growth of the deprived neurons after 4 days of age.<\/jats:p>","DOI":"10.1002\/cne.902020307","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T20:25:47Z","timestamp":1117225547000},"page":"373-384","source":"Crossref","is-referenced-by-count":47,"title":["Age\u2010 and position\u2010dependent effects of monaural acoustic deprivation in nucleus magnocellularis of the chicken"],"prefix":"10.1002","volume":"202","author":[{"given":"John W.","family":"Conlee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas N.","family":"Parks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(70)90227-0"},{"key":"e_1_2_1_3_1","first-page":"67","volume-title":"Current Topics in Developmental Biology, Vol. 15, Neural Development, Pt. 1, Emergence of Specificity in Neurons","author":"Berry M.","year":"1980"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb20444.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901200305"},{"key":"e_1_2_1_6_1","first-page":"555","article-title":"Effects of visual deprivation on the development of visual pathways in the Galago","volume":"3","author":"Casagrande V. A.","year":"1977","journal-title":"Neurosci. Abstr."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(72)90038-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1152\/jn.1977.40.6.1275","article-title":"Plasticity of binaural interaction. II. Critical period and changes in midline response","volume":"40","author":"Clopton B. M.","year":"1977","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_9_1","first-page":"271","volume-title":"Morphogenesis and Malformation of the Ear","author":"Clopton B. M.","year":"1980"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(79)90231-0"},{"key":"e_1_2_1_11_1","first-page":"819","article-title":"Age\u2010 and position\u2010dependent effects of acoustic deprivation in the avian n. magnocellularis","volume":"6","author":"Conlee J. W.","year":"1980","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520297409117007"},{"issue":"60","key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/00034894790880S505","article-title":"Influence of otitis media on hearing and development","volume":"88","author":"Dobie R. A.","year":"1979","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90112-2"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4684-3605-1","volume-title":"Developmental Neurobiology of Vision","author":"Freeman R. D.","year":"1979"},{"key":"e_1_2_1_16_1","first-page":"9","volume-title":"Developmental Neuropsychology of Sensory Deprivation","author":"Globus A.","year":"1975"},{"key":"e_1_2_1_17_1","first-page":"237","volume-title":"Behavioral Embryology","author":"Gottlieb G.","year":"1976"},{"key":"e_1_2_1_18_1","first-page":"626","article-title":"Acoustic experience modifies dendritic form in nucleus laminaris, Soc","volume":"5","author":"Gray L.","year":"1979","journal-title":"Neurosci. Abstr."},{"key":"e_1_2_1_19_1","first-page":"149","article-title":"The effect of lid suture upon the growth of cells in the dorsal lateral geniculate nucleus of kittens","volume":"124","author":"Guillery R. W.","year":"1973","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901720206"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901770110"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1963.26.6.994"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1976.040.01.054"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1977.0050"},{"key":"e_1_2_1_25_1","first-page":"22","article-title":"Plasticity of binaural input to neurons in cat inferior colliculus","volume":"5","author":"Irvine D. R. F.","year":"1979","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0077496"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4951-9"},{"key":"e_1_2_1_28_1","volume-title":"Hearing Loss in Children","author":"Jaffe B.","year":"1977"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","unstructured":"Jhaveri S. R. andD. K.Morest(1981a) Neuronal architecture in nucleus magnocellularis of the chicken auditory system with observations on nucleus laminaris: A light and electron microscope study.Neuroscience(in press).","DOI":"10.1016\/0306-4522(82)90045-8"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","unstructured":"Jhaveri S. R. andD. K.Morest(1981b) Sequential alterations of neuronal architecture in nucleus magnocellularis of the developing chicken: A Golgi study.Neuroscience(in press).","DOI":"10.1016\/0306-4522(82)90046-X"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","unstructured":"Jhaveri S. R. andD. K.Morest(1981c) Sequential alterations of neuronal architecture in nucleus magnocellularis of the chicken: An electron microscope study.Neuroscience(in press).","DOI":"10.1016\/0306-4522(82)90047-1"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901890305"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1037\/0097-7403.5.2.97"},{"key":"e_1_2_1_34_1","first-page":"624","article-title":"Effects of peripheral auditory system damage on the structure of the inferior colliculus of the rat","volume":"187","author":"Killackey H. P.","year":"1977","journal-title":"Anat. Rec."},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jmor.1051210302","article-title":"Correlation of the development of membranous and bony labyrinths, sensory ganglia, nerves, and brain centers of the chick embryo","volume":"21","author":"Knowlton V. Y.","year":"1967","journal-title":"J. Morphol."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-609301-8.50014-3"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901830313"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902020105"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","unstructured":"Parks T. N.(1982) Morphology and origin of axosomatic endings in an avian cochlear nucleus: Nucleus magnocellularis of the chicken.J. Comp. Neurol.(in press).","DOI":"10.1002\/cne.902030307"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901640404"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901800303"},{"key":"e_1_2_1_42_1","series-title":"National Technical Information Service Publication No. PB205473, published 1971","first-page":"774","volume-title":"Histologie du System Nerveux de l'Homme et des Vertebres. I","author":"Ram\u00f3n y Cajal S.","year":"1909"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901640403"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901660408"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902020309"},{"key":"e_1_2_1_46_1","first-page":"303","article-title":"Plasticity of the developing auditory system","volume":"88","author":"Ruben R. J.","year":"1980","journal-title":"Ann. Otol."},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-8074-0_11"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90076-0"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012421"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901610204"},{"key":"e_1_2_1_51_1","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1152\/jn.1977.40.6.1266","article-title":"Plasticity of binaural interaction. I. Effects of early auditory deprivation","volume":"40","author":"Silverman M. S.","year":"1977","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901530202"},{"key":"e_1_2_1_53_1","doi-asserted-by":"crossref","unstructured":"Smith Z. D. J.(1981) Organization and development of brain stem auditory nuclei of the chicken: Dendritic development of n. laminaris.J. Comp. Neurol.(in press).","DOI":"10.1002\/cne.902030302"},{"key":"e_1_2_1_54_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1037\/h0026147","article-title":"A control group design for experimental studies of developmental processes","volume":"70","author":"Solomon R. L.","year":"1969","journal-title":"Psychol Bull."},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0024619"},{"key":"e_1_2_1_56_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0006-8993(76)90772-1","article-title":"The effects of monocular visual deprivation: Disuse or binocular interactions","volume":"111","author":"von Noorden G. K.","year":"1975","journal-title":"Brain Res."},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1977.00780240050006"},{"key":"e_1_2_1_58_1","first-page":"684","article-title":"Effects of neonatal conductive hearing loss on brain stem auditory nuclei","volume":"88","author":"Webster D. B.","year":"1979","journal-title":"Ann. Otol."},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1963.26.6.978"},{"key":"e_1_2_1_60_1","volume-title":"Statistical Principles in Experimental Design","author":"Winer B. J.","year":"1971"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902020307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902020307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T01:18:51Z","timestamp":1696641531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902020307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,11]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,11]]}},"alternative-id":["10.1002\/cne.902020307"],"URL":"https:\/\/doi.org\/10.1002\/cne.902020307","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,11]]}}}