{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T15:01:28Z","timestamp":1725548488500},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":8267,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1982,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Weanling hamsters were inoculated intracerebrally with brain suspensions from normal or scrapie\u2010infected hamsters. A third group of uninoculated animals was fed cuprizone. Histologic and electron microscopic examination of the neural retinas and retinal pigment epithelium was done. At 50 days postinoculation, when scrapie\u2010infected animals began to show clinical signs of encephalopathy, there was a variable degree of photoreceptor degeneration. By the time animals were moribund, at 74 days postinoculation, photoreceptor degeneration was severe, as demonstrated by loss of most outer and inner segments and cell bodies. The outer plexiform, inner nuclear, and inner plexiform layers were reduced in thickness. Some retinal pigment epithelial cells contained lipoidal inclusions. The neural retinas and retinal pigment epithelium of noninfected and cuprizone\u2010treated animals were normal. We have previously shown that the scrapie agent accumulates in the retina; that together with our present work, we conclude that the scrapie agent is the cause of photoreceptor degeneration in experimentally inoculated hamsters.<\/jats:p>","DOI":"10.1002\/cne.902050206","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:49:44Z","timestamp":1104598184000},"page":"153-160","source":"Crossref","is-referenced-by-count":21,"title":["Retinal degeneration during clinical scrapie encephalopathy in hamsters"],"prefix":"10.1002","volume":"205","author":[{"given":"Ned","family":"Buyukmihci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faye","family":"Goehring\u2010Harmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard F.","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"OP\u2010667","article-title":"Inherited retinal degenerations in the dog","volume":"81","author":"Aguirre G.","year":"1976","journal-title":"Trans. Am. Acad. Ophthalmol. Otol."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.210508"},{"key":"e_1_2_1_4_1","first-page":"319","article-title":"Ocular effects of scrapie agent in hamsters: Preliminary observations","volume":"16","author":"Buyukmihci N.","year":"1977","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.2.1169"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902050105"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.186.4162.449"},{"key":"e_1_2_1_8_1","unstructured":"Gustafson D. P. andC. H.Lamar(1974)Adenosine 3\u2032 5\u2032monophosphate in scrapied mice. Am. Soc. Microbiol. 7th Annual Mtg. p.251(abstract V302)."},{"key":"e_1_2_1_9_1","first-page":"34","article-title":"Progressive retinal degeneration scrapie\u2010infected hamsters","volume":"44","author":"Hogan R. N.","year":"1981","journal-title":"Lab. Invest."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(76)90038-4"},{"key":"e_1_2_1_11_1","first-page":"487","article-title":"Electron microscopic observations of human retinitis pigmentosa, dominantly inherited","volume":"13","author":"Kolb H.","year":"1974","journal-title":"Invest. Ophtalmol."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/280062a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.193183"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(68)91523-7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/131.2.104"},{"key":"e_1_2_1_16_1","first-page":"450","article-title":"Retinal damage by light in rats","volume":"5","author":"Noell W. K.","year":"1966","journal-title":"Invest. Opthalmol."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098587100800106"},{"key":"e_1_2_1_18_1","first-page":"338","article-title":"Experimental allergic optic neuritis in guinea pigs: Preliminary report","volume":"16","author":"Rao N. A.","year":"1977","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(71)91587-X"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.42.2.392"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902050206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902050206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T04:18:34Z","timestamp":1699849114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902050206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,2,20]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,2,20]]}},"alternative-id":["10.1002\/cne.902050206"],"URL":"https:\/\/doi.org\/10.1002\/cne.902050206","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,2,20]]}}}