{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:37:23Z","timestamp":1791250643825,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":7447,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1984,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The reciprocal connections between the septum and the entorhinal area (EA) was studied in the rat brain using antero\u2010 and retrograde axonal transport methods. After injections of large volumes (2 \u00d7 100 nl) of horseradish peroxidase (HRP) conjugated to wheat\u2010germ agglutinin (WGA) into the medial septum (MS) and the diagonal band of Broca (dbB), anterogradely transported HRP\u2010WGA was found primarily in layers II and IV of the medial and lateral EA. Injections of HRP\u2010WGA (50\u2013100 nl) or fluorescent dyes (50\u2013100 nl) into different parts of the retrohippocampal region resulted in labeling, by retrograde axonal transport, of cells in the MS and dbB, both ipsi\u2010 and contralateral to the injected hemisphere. The labeled cells were either small (long axis of soma: 10\u201315 \u03bcm), round, and oval, or medium (15\u201325 \u03bcm) to large (25\u201335 \u03bcm) of fusiform or multipolar shape. By using the method of retrograde fluorescent double labeling, the septal afferents to the EA were found to give off collaterals to other parts of the hippocampal region. A much smaller number of septal cells appeared to send bilateral projections to the EA of both hemispheres. Studies employing retrograde transport of HRP in combination with acetylcholinesterase (AChE) histochemistry on the same tissue section showed that, while a large number of cells projecting to the EA contain AChE, many projecting cells are devoid of AChE reaction products. These findings suggest that the septo\u2010entorhinal projection consists of a cholinergic as well as a noncholinergic component.<\/jats:p>\n                  <jats:p>The entorhinal efferents to the septum were studied after injections of HRP\u2010WGA into different parts of the retrohippocampal region. Labeled fibers could be traced through the fimbria to their terminal fields in the intermediate parts of the lateral septal nucleus and to the most lateral aspect of the vertical limb of the dbB. The cells giving rise to this projection were situated in layer IV of the medial and layers II through V of the lateral EA. Taken together, the present findings demonstrate a close anatomical relationship between the septum and the entorhinal area, in addition to the better known connections between the septum and the Ammon's horn.<\/jats:p>","DOI":"10.1002\/cne.902250303","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:09:36Z","timestamp":1104588576000},"page":"327-343","source":"Crossref","is-referenced-by-count":200,"title":["A study of the reciprocal connections between the septum and the entorhinal area using anterograde and retrograde axonal transport methods in the rat brain"],"prefix":"10.1002","volume":"225","author":[{"given":"Angel","family":"Alonso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"K\u00f6hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90021-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1966.tb03223.x"},{"key":"e_1_2_1_4_1","volume-title":"The Septum of the Cat","author":"Andy O. 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