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On the basis of their clustering patterns, hypothalamic TH neurons could be subdivided into two groups: dorsal and ventral. The <jats:italic>ventral<\/jats:italic> group consists of a prominent aggregate of cells located in the caudal part of the arcuate nucleus. From here, cells extend around the caudal part of the ventromedial and dorsomedial nuclei and the base of the diencephalon. Tyrosine hydroxylase\u2010positive cells are present throughout the arcuate nucleus, except in its ventromedial part. Anteriorly, immunoreactive cells appear in the suprachiasmatic and supraoptic nuclei, in the retrochiasmatic area, and in the ventral part of the anterior hypothalamic nucleus. The <jats:italic>dorsal<\/jats:italic> group has its main concentration of cells in the medial part of the zona incerta, from which two clusters of cells, one medial and one lateral, extend rostralward. The medial group comprises cells in the medial part of the dorsomedial, paraventricular, and anterior hypothalamic nuclei. These cells adjoin the periventricular cells. The lateral group of cells emanating from the zona incerta occupies the lateral part of the dorsomedial and anterior hypothalamic nuclei and the dorsal hypothalamic area. The <jats:italic>dorsal<\/jats:italic> and <jats:italic>ventral<\/jats:italic> TH cell groups are in continuity medially in the periventricular layer, and laterally through the cells that surround the ventromedial nucleus.<\/jats:p><jats:p>Although the cells vary widely in size, shape, and dendritic arborization pattern, there are two main cell types. Small (21 \u00d7 11 \u03bcm), round to fusiform cells, with two or three dendrites arborizing simply, were frequently seen in the arcuate, suprachiasmatic, periventricular, supramammillary nuclei and at the borders of the ventromedial nucleus. The other cell type is larger (40 \u00d7 15 \u03bcm) and multipolar, with three to five frequently branching dendrites. The dendritic field is large and the cells are intensely TH\u2010immunoreactive. Although the larger cells occur occasionally in every hypothalamic nucleus, their principal locations are in the dorsal parts of the dorsomedial, posterior hypothalamic nuclei and the dorsal and lateral parts of the zona incerta, and in the areas dorsal and medial to the mammillothalamic tract at caudal hypothalamic levels. In this paper we give a detailed description of TH\u2010immunoreactive fibers and terminals in the hypothalamus and a comparison with previous studies of catecholamine cells in the hypothalamus.<\/jats:p>","DOI":"10.1002\/cne.902270403","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T19:14:40Z","timestamp":1104606880000},"page":"467-496","source":"Crossref","is-referenced-by-count":155,"title":["Distribution of tyrosine\u2010hydroxylase\u2010immunoreactive neurons in the hypothalamus of rats"],"prefix":"10.1002","volume":"227","author":[{"given":"Victoria","family":"Chan\u2010Palay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Z\u00e1borszky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"K\u00f6hler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menek","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanford L.","family":"Palay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"954","article-title":"Development of the diencephalon in the rat. 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