{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:59:58Z","timestamp":1791133198207,"version":"4.1.0"},"reference-count":92,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":7282,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The thalamo\u2010cortical and cortico\u2010cortical afferents of the cat's insular cortex were investigated with the retrograde horseradish peroxidase technique. The most prominent loci of thalamic labeling were the suprageniculate nucleus and parts of the posterolateral nucleus. Injections into the anterior part of the insular cortex also resulted in labeled cells in the ventromedial posterior nucleus and in the intralaminar nuclei, while injections into posterior parts revealed projections from the medial and dorsal parts of the medial geniculate nucleus. Only the anterior and most ventral parts of the insular cortex overlying the anterior rhinal sulcus were connected with the mediodorsal nucleus of the thalamus. All injections into the gyrus sylvius anterior showed a specific pattern of cortical afferents: With the exception of the labeling in the prefrontal cortex and the inferotemporal region, the labeled cells were very narrowly restricted to the presylvian, the suprasylvian, and the splenial sulcus.<\/jats:p><jats:p>The thalamic neurons projecting to the cortex were generally organized in a bandlike pattern which crossed nuclear borders. The majority of the cortico\u2010cortical connections originated from sulcal areas next to the prefrontal, parietal, and cingulate cortex, that is, next to so\u2010called association cortices.<\/jats:p><jats:p>In the light of the present results the role of the insular cortex as a multifunctional association area is discussed, as well as its relation to other cortical centers.<\/jats:p>","DOI":"10.1002\/cne.902290309","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T19:18:56Z","timestamp":1104607136000},"page":"393-418","source":"Crossref","is-referenced-by-count":57,"title":["Cortical and thalamic afferent connections of the insular and adjacent cortex of the cat"],"prefix":"10.1002","volume":"229","author":[{"given":"W. O.","family":"Guldin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J.","family":"Markowitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"696","article-title":"Ascending and descending connections of the insular cortex of the cat","volume":"107","author":"Avanzini G.","year":"1969","journal-title":"Arch. Ital Biol."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(75)90131-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(68)90100-5"},{"key":"e_1_2_1_5_1","volume-title":"The Brain Stem of the Cat. A Cytoarchitectonic Atlas with StereotaxicCoordinates","author":"Berman A. L.","year":"1968"},{"key":"e_1_2_1_6_1","volume-title":"A Cytoarchitectonic Atlas wild Stereotaxic Coordinates","author":"Berman A. L.","year":"1982"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901740204"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90778-3"},{"key":"e_1_2_1_9_1","series-title":"Progress in Brain Research","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0079-6123(08)60024-2","volume-title":"Molecular and Cellular Interactions Underlying Higher Brain Functions","author":"Berson D. M.","year":"1983"},{"key":"e_1_2_1_10_1","first-page":"249","article-title":"Die Cyto\u2010 und Myeloarchitektur des Cortex claustralis und des Claustrum beim Menschen","volume":"49","author":"Brockhaus H.","year":"1940","journal-title":"J. Psychol. Neurol. (Leipzig)"},{"key":"e_1_2_1_11_1","volume-title":"Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues","author":"Brodmann K.","year":"1909"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901680204"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902240203"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1523\/JNEUROSCI.03-11-02365.1983","article-title":"Ascending projections to the medial geniculate body of the cat: Evidence for multiple, parallel auditory pathways through thalamus","volume":"3","author":"Calford M. B.","year":"1983","journal-title":"J. Neurosci."},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1152\/jn.1954.17.3.271","article-title":"Responses from an association area secondarily activated from optic cortex","volume":"17","author":"Clare M. H.","year":"1954","journal-title":"J. Neurophysiol."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.910060202"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90207-4"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90447-7"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(74)90175-9"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90575-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0361-9230(78)90054-0","article-title":"Spatio\u2010temporal pattern discrimination in cats with insular\u2010temporal lesions","volume":"3","author":"Colavita F. B.","year":"1978","journal-title":"Brain Res. Bull."},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0031-9384(79)90322-6","article-title":"Insular cortex and perception of temporal patterns","volume":"22","author":"Colavita F. B.","year":"1969","journal-title":"Physiol. Behav."},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1037\/h0024142","article-title":"Loss of auditory pattern discrimination following insular\u2010temporal lesions in the cat","volume":"63","author":"Cornwall P.","year":"1967","journal-title":"J. Comp. Physiol. Psychol."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90730-7"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902200205"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90247-0"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(77)90009-X"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90805-3"},{"key":"e_1_2_1_29_1","first-page":"296","article-title":"Preliminary report on results of electrical stimulation of the island of Reil in the macaque","volume":"121","author":"Frontera J. G.","year":"1955","journal-title":"Anat. Rec."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90066-6"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90369-1"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90420-4"},{"key":"e_1_2_1_33_1","first-page":"286","volume-title":"The Organization of the Cerebral Cortex","author":"Graybiel A. M.","year":"1981"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902150203"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF02322228","article-title":"Zur Cytoarchitectonik der Gro\u00dfhirnrinde der Feliden","volume":"87","author":"Gurewitsch M.","year":"1928","journal-title":"Z. Ges. Anat. Abt. I."},{"key":"e_1_2_1_36_1","first-page":"283","volume-title":"Handbook of Sensory Physiology, Vol. V\/1: Auditory System","author":"Harrison J. M.","year":"1974"},{"key":"e_1_2_1_37_1","first-page":"377","article-title":"Architektonischer Aufbau des somatosensorischen und parietalen Cortex der Katze","volume":"6","author":"Hassler R.","year":"1964","journal-title":"J. Hirnforsch."},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901410402"},{"key":"e_1_2_1_39_1","unstructured":"Holl M.(1899) Ueber die Insel des Carnivorengehirnes.Arch. Anat. Physiol. Anat. Abt.:217\u2013266."},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901930408"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00235889"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90088-4"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901430204"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1949.12.5.347"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90620-3"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236173"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901720408"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90633-4"},{"key":"e_1_2_1_49_1","volume-title":"Die Morphologie des Stirnlappens und der Insel der Anthropomorphen","author":"Marchand F.","year":"1983"},{"key":"e_1_2_1_50_1","first-page":"233","article-title":"Widespread cortical projections of the ventral tegmental area and of other brain stem structures in the cat","volume":"41","author":"Markowitsch H. J.","year":"1981","journal-title":"Exp. Brain Res."},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.84.5.817"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(78)90035-0"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90587-5"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03326611"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01964374"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238706"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(80)90046-7"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(80)90193-1"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/24.12.63512"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902120102"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902120104"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/27.3.113450"},{"key":"e_1_2_1_63_1","volume-title":"Der Bau der Gro\u00dfhirnrinde und seine \u00f6rtlichen Verschiedenheiten nebst einem pathologisch\u2010anatomischen Corollarium","author":"Meynert T. C.","year":"1869"},{"key":"e_1_2_1_64_1","first-page":"611","article-title":"The architecture of the medial geniculate body of the cat","volume":"98","author":"Morest D.","year":"1964","journal-title":"J. Anat."},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238092"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902120103"},{"key":"e_1_2_1_67_1","first-page":"303","article-title":"The dorsal thalamus of the cat and comparison with monkey and man","volume":"14","author":"Niimi K.","year":"1973","journal-title":"J. Hirnforsch."},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67353-5_1"},{"key":"e_1_2_1_69_1","first-page":"326","article-title":"Cortical projections of the medial geniculate body in the cat","volume":"19","author":"Niimi K.","year":"1973","journal-title":"Exp. Brain Res."},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00234921"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/78.4.445"},{"key":"e_1_2_1_72_1","first-page":"1256","article-title":"Afferent connections of dorsal and ventral agranular insular cortex in the hamster Mesocricetus auratus","volume":"7","author":"Reep R. L.","year":"1982","journal-title":"Neuroscience"},{"key":"e_1_2_1_73_1","first-page":"195","article-title":"Die sylvische Furche","volume":"9","author":"Reil J. C.","year":"1809","journal-title":"Arch. Physiol. (Halle)"},{"key":"e_1_2_1_74_1","volume-title":"Topographischer Hirnatlas der Katze f\u00fcr experimental\u2010physiologische Untersuchungen","author":"Reinoso\u2010Su\u00e1rez F.","year":"1961"},{"key":"e_1_2_1_75_1","first-page":"1","article-title":"Insular and opercular cortex and its thalamic projections in Macaca mulatta","volume":"92","author":"Roberts T. S.","year":"1963","journal-title":"Schweiz. Arch. Neurol. Neurochir. Psychiatr."},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901920106"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00235548"},{"key":"e_1_2_1_78_1","first-page":"467","article-title":"Die Insel des Menschen und der Tiere","volume":"37","author":"Rose M.","year":"1928","journal-title":"J. Psychol. Neurol. (Leipzig)"},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(68)90174-1"},{"key":"e_1_2_1_80_1","first-page":"79","article-title":"Cyto\u2010 and myeloarchitecture of the visual cortex of the cat and surrounding integration cortices","volume":"11","author":"Sanides F.","year":"1969","journal-title":"J. Hirnforsch."},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901170109"},{"key":"e_1_2_1_82_1","volume-title":"Handbuch der mikroskopischen Anatomie des Menschen","author":"Stephan H.","year":"1975"},{"key":"e_1_2_1_83_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(71)90521-X","article-title":"Unit study of exteroceptive input to the claustrocortex in awake, sitting squirrel monkeys","volume":"28","author":"Sudakov K.","year":"1971","journal-title":"Brain Res."},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902200110"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902120202"},{"key":"e_1_2_1_86_1","first-page":"477","volume":"201","author":"Updike B. V.","year":"1981","journal-title":"Projections from visual area of the middle suprasylvian sulcus in the cat"},{"key":"e_1_2_1_87_1","first-page":"12","article-title":"A revaluation of the functional organization and cytoarchitecture of the feline lateral posterior complex, with observations on adjoining cell groups","volume":"219","author":"Updike B. B.","year":"1983","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901760307"},{"key":"e_1_2_1_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-12-02629.1983"},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902240304"},{"key":"e_1_2_1_91_1","volume-title":"An Anatomical Guide to Experimental Researches on the Cat's Brain","author":"Winkler C.","year":"1914"},{"key":"e_1_2_1_92_1","first-page":"165","volume-title":"Neural Mechanisms of the Auditory and Vestibular Systems","author":"Woolsey C. N.","year":"1960"},{"key":"e_1_2_1_93_1","first-page":"235","volume-title":"Sensory Communication","author":"Woolsey C. N.","year":"1961"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902290309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902290309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T11:59:06Z","timestamp":1697803146000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902290309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":92,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,11]]}},"alternative-id":["10.1002\/cne.902290309"],"URL":"https:\/\/doi.org\/10.1002\/cne.902290309","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}