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Both the age of the subjects at the time of cochlea (basilar papilla) removal (1\u201366 weeks) and the survival period (1\u201345 days) were varied. Neuron number and soma cross\u2010sectional area were determined from Nissl stained sections. Additional material was processed to examine the relationship of ganglion cell loss to changes in n. magnocellularis.<\/jats:p><jats:p>Neuron number decreased by 25\u201330% and soma cross\u2010sectional area decreased by 10\u201320% ipsilateral to the cochlea removal in chickens operated on during the first 6 weeks after hatching. In contrast, in chickens operated on at 66 weeks posthatch neuron number decreased less than 10% and there was no change in soma area. The changes were rapid, being nearly complete 2 days after cochlea removal. An initial change (1 and 2 days after surgery) observed in animals operated on up to 6 weeks posthatch was the presence of a large number of neurons in which no Nissl substance could be detected. These results demonstrate an age\u2010dependent change in the susceptibility of NM neurons to deafferentation. This change is not temporally related to other measures of functional maturation of the auditory system.<\/jats:p>","DOI":"10.1002\/cne.902310403","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T19:23:56Z","timestamp":1104607436000},"page":"435-445","source":"Crossref","is-referenced-by-count":206,"title":["Afferent influences on brain stem auditory nuclei of the chicken: Neuron number and size following cochlea removal"],"prefix":"10.1002","volume":"231","author":[{"given":"Donald E.","family":"Born","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin W.","family":"Rubel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348946307200119"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90658-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090650110"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb20444.x"},{"key":"e_1_2_1_6_1","first-page":"843","article-title":"Cochlea removal eliminates physiological activity in brain stem auditory nuclei of the chicken","volume":"10","author":"Born D. 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