{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T19:10:45Z","timestamp":1697915445378},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":7176,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1985,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the preceding study (Edwards et al., 1985), we showed that regenerating optic axons reestablish a topographically restricted projection to a caudal tectal island created by surgical removal of a 1\u2010mm\u2010wide strip of caudal tectum in goldfish. In the present ultrastructural study, we evaluated the dependence of this axonal outgrowth on the presence of tectal target tissue caudal to the gap. Axon counts in the lesion zone were compared between cases with complete caudal tectal ablation and cases with ablation sparing a caudal tectal island (with and without optic nerve crush). During the postoperative interval of 20\u201350 days (early period), up to about 1,000 unmyelinated axons with features characteristic of optic axons were present in numerous small subpial bundles in both preparations. In the subsequent interval of 50\u2013110 days (middle period), less than 200 axons were counted caudal to simple half\u2010tecta, whereas 4,000\u201314,000 myelinated and unmyelinated axons were present in a few large bundles which crossed the lesion zone of tectal island cases. In this period, optic terminals could be demonstrated in the tectal island using the anterograde horseradish peroxidase method. At 170\u2013300 days after surgery (Late period), bridging bundles contained between 2,000 and 6,000 largely myelinated axons. We conclude that caudal tectal tissue is not necessary for the initial outgrowth of a small number of axons beyond a rostral half\u2010tectum. The target is essential, however, for the maintenance of these axon fascicles and for the subsequent massive outgrowth of axons to the island. The contributions of glial guidance, diffuse exploratory outgrowth, and target\u2010produced trophic factors to the formation of an initially exuberant projection to the island are discussed. A process of selective axon collateral withdrawal is proposed to account for the decrease in axon numbers within bridging bundles in the late period and for the late restriction in the retinal origin of the island projection indicated by results in the preceding study (Edwards et al., '85).<\/jats:p>","DOI":"10.1002\/cne.902320310","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T19:26:20Z","timestamp":1104607580000},"page":"386-400","source":"Crossref","is-referenced-by-count":4,"title":["Selective retinal reinnervation of a surgically created tectal island in goldfish. II. Electron microscopic analysis"],"prefix":"10.1002","volume":"232","author":[{"given":"M. A.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","unstructured":"Adler R.(1982) Regulation of neurite growth in purified retina neuronal cultures: Effects of PNPF a substratum\u2010bound neurite\u2010promoting factor.J. Neurosci. Res.165\u2013177.","DOI":"10.1002\/jnr.490080207"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90061-9"},{"key":"e_1_2_1_4_1","first-page":"149","article-title":"Pioneer growth cones in virgin mesenchyme","volume":"68","author":"Al\u2010Ghaith L. K.","year":"1982","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.ph.45.030183.003125","article-title":"New neurotrophic factors","volume":"45","author":"Barde Y.\u2010A.","year":"1982","journal-title":"Ann. Rev. Physiol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90453-0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6194562"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01181746"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)91004-0"},{"key":"e_1_2_1_10_1","first-page":"129","article-title":"Development of fine structure of spinal cord in monkey fetuses I. The motoneuron neuropil at the time of onset of reflex activity","volume":"119","author":"Bodian D.","year":"1966","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(82)90233-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0165-3806(83)90061-5","article-title":"Organotypic cultures of neuronal retina: Neurite outgrowth stimulated by brain extracts","volume":"6","author":"Carri N. G.","year":"1982","journal-title":"Dev. Brain Res."},{"key":"e_1_2_1_13_1","first-page":"53","article-title":"Sympathetic nerve fibers ingrowth in the central nervous system of neonatal rodents upon intracerebral NGF injections","volume":"116","author":"Chen M. G. M.","year":"1978","journal-title":"Arch. Ital. Biol."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901770106"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.10.5210"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90599-0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(81)90032-8"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00521105"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/icb\/22.1.153","article-title":"The patterning of neuronal connections","volume":"22","author":"Diamond J.","year":"1982","journal-title":"Am. Zool"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(80)90060-3"},{"key":"e_1_2_1_21_1","first-page":"145","article-title":"The paths and destinations of the induced ipsilateral retinal projection in goldfish","volume":"45","author":"Easter S. S.","year":"1978","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_22_1","first-page":"289","article-title":"Control of neurite extension by embryonic heart explants","volume":"61","author":"Ebendal T.","year":"1981","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(77)90135-5"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902260110"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902320309"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.901870102","article-title":"Golgi and EM studies of the formation of dendritic and axonal arbors: The interneurons of the substantial gelatinosa of Rolando in newborn kittens","volume":"187","author":"Falls W.","year":"1978","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402110209"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/275746a0"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.87.3.546"},{"key":"e_1_2_1_30_1","first-page":"601","article-title":"S. Ram\u00f3n y Cajal, R. G. Harrison and the beginnings of neuroembryology","volume":"24","author":"Hamburger V.","year":"1980","journal-title":"Perspect. Biol. Med."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900370107"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(67)90031-3"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6243417"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112660"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901810303"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4951-9"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490080221"},{"key":"e_1_2_1_38_1","first-page":"171","volume-title":"Neurobiology of Cerebellar Evolution and Development","author":"Kaiserman\u2010Abramof I. R.","year":"1969"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(80)90151-7"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901890206"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01175572"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.68.2.357"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01205016"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901540105"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90884-2"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01208508"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90017-7"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901680202"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902090405"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902090406"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902090407"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901800211"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902190203"},{"key":"e_1_2_1_54_1","first-page":"1","article-title":"Growth characteristics of adrenergic nerves in the adult rat. Fluorescence, histochemical, and 3H\u2010noradrenaline uptake studies using tissue transplantation to the anterior chamber of the eye","volume":"348","author":"Olson L.","year":"1970","journal-title":"Acta Physiol. Scand. [Suppl.]"},{"key":"e_1_2_1_55_1","volume-title":"The Fine Structure of the Nervous System","author":"Peters A.","year":"1976"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90667-9"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(80)90009-9"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902000308"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901650103"},{"key":"e_1_2_1_60_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0165-3806(83)90080-9","article-title":"Directional growth of sympathetic nerve fibers in vitro towards enteric smooth muscle and heart from mice with congenital aganglionic colon and their normal littermates","volume":"7","author":"Rawdon B. B.","year":"1983","journal-title":"Dev. Brain Res."},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001350113"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902050108"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01262414"},{"key":"e_1_2_1_64_1","volume-title":"Recent Achievements in Restorative Neurology, Upper Motoneurone Function and Disfunction","author":"Schneider G. E.","year":"1984"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90001-X"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90073-6"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90072-4"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(77)90018-8"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90480-1"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90013-5"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901990107"},{"key":"e_1_2_1_72_1","first-page":"210","article-title":"Growth cone guidance in the chick hindlimb","volume":"9","author":"Tosney K. W.","year":"1983","journal-title":"Soc. Neurosci. Abstr."}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902320310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902320310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T16:23:26Z","timestamp":1697819006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902320310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2,15]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,2,15]]}},"alternative-id":["10.1002\/cne.902320310"],"URL":"https:\/\/doi.org\/10.1002\/cne.902320310","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,2,15]]}}}