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Animals were killed at 2, 5, 10, 20, 35, 65, and 115 days after crush injury to the hypoglossal nerve. At 5 days after surgery, growth cones and regenerating unmyelinated axons were present at the lesion site, but no conspicuous changes were apparent in the nerve cell bodies. At 10 days after surgery, the granular endoplasmic reticulum was disaggregated and depleted. The elongation phase appeared to be completed at 20 days, as judged by the bilateral retrograde labeling of the hypoglossal nuclei with horseradish peroxidase. By 35 days, the cytoarchitecture of the nerve cell bodies and maturation of axons, as determined by a comparison of the relative frequency distribution of cross sectional areas proximal and distal to the lesion, were completely restored. Comparative quantitative light microscopic examination of the hypoglossal nuclei of intact and experimental animals failed to reveal any statistically significant differences in the total number of glial cells, number of glial cells\/unit area of neuropil, or relative proportions of glial cell types at any of the postoperative time intervals. Moreover, electron microscopic quantitation of the microglial cell population did not reveal any significant alterations in the number, density, location, or morphology of these cells. These results demonstrate that perineuronal glial cell proliferation or changes in the composition of the glial cell population are not attendant on retrograde changes in the cat hypoglossal nucleus or a necessary concomitant to successful axon regeneration.<\/jats:p>","DOI":"10.1002\/cne.902330402","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T19:27:46Z","timestamp":1104607666000},"page":"421-428","source":"Crossref","is-referenced-by-count":14,"title":["A morphological study of glial cells in the hypoglossal nucleus of the cat during nerve regeneration"],"prefix":"10.1002","volume":"233","author":[{"given":"John L.","family":"Cova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"Aldskogius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1982.tb00303.x"},{"key":"e_1_2_1_3_1","first-page":"7","volume-title":"Spinal Cord Reconstruction","author":"Barren K. 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