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Within the first 3 weeks postgraft surgery (WPS), the nerve\u2010tectum interface became firmly established. Concomitant with this was an invasion of the host tectum by a small number of fine \u201cpioneerlike\u201d axons from the nerve. By 6 WPS there developed a concerted instreaming of a large number of peripheral fibers. Once within the CNS, the foreign axons distributed themselves throughout the rostrocaudal extent of the tectum, but primarily its dorsal aspect within superficial layers 8 and 9.<\/jats:p><jats:p>Presence of intact optic fibers at the time of mandibular fiber invasion served somewhat to restrict the regenerating aberrant axons in their course through layer 9. This restriction could be avoided by removal of the optic input either before or during peripheral ingrowth. However, once peripheral fibers had entered and established themselves in the host environment, no subsequent manipulation of the retinotectal projection had any effect.<\/jats:p><jats:p>The aberrant growth pattern, which appeared remarkably stable after 6 WPS, consisted of a plexus of medium\u2010 and fine\u2010caliber peripheral axons. Many of these fibers had numerous branches and \u201c<jats:italic>en passant<\/jats:italic>\u201d varicosities, the latter encompassing a variety of shapes and sizes. Terminal swellings and arborizations were also found.<\/jats:p><jats:p>When comparing the regeneration of optic and mandibular nerve fibers in the tectum, two distinctions were made. Whereas optic axons revealed a fascicular and layered organization, mandibular axons showed a highly segregated and disordered growth pattern. These characteristic differences were maintained even when the two fiber systems were allowed to coregenerate into the same target tectum. Thus, each of the two groups of axons interacts with the tectal substrate in a distinct manner, apparently independent of the other.<\/jats:p>","DOI":"10.1002\/cne.902350310","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T19:31:09Z","timestamp":1104607869000},"page":"395-415","source":"Crossref","is-referenced-by-count":5,"title":["Peripheral nerve grafts to the frog optic tectum: A morphological study of foreign axon regeneration in the central nervous system"],"prefix":"10.1002","volume":"235","author":[{"given":"Elliot I.","family":"Kaplan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine D.","family":"Clemente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"169","article-title":"De l'\u00e9volution de la n\u00e9vroglie, et sp\u00e9cialment de ses relation avec l'appareil vasculaire","volume":"13","author":"Achucarro N.","year":"1915","journal-title":"Trab. 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