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Neurons or neuronal processes containing CCK\u2010I were localized within all laminae of the olfactory bulb except the olfactory nerve fiber layer. A large population of CCK\u2010I neurons, with morphology, size, and distribution corresponding to that of the middle and external tufted cells, was observed within a zone extending from the deep periglomerular region through the superficial one\u2010half to one\u2010third of the external plexiform layer. A smaller number of immunoreactive perikarya were found in the deep external plexiform layer, the glomerular layer, and rarely within the inner plexiform layer. These CCK\u2010I neurons appeared to correspond to internal tufted cells, periglomerular cells, and deep short\u2010axon cells, respectively. Dense CCK\u2010I staining of fibers and terminals was present within the internal plexiform layer and, less densely, within the neuropil of the granule cell layer. In addition, terminal\u2010like CCK\u2010I was localized within layer 1A of the anterior olfactory nucleus, the olfactory tubercle, and the most rostral piriform cortex. This observation provides corroboration for the identification of the principal CCK\u2010I neuron in the rat olfactory bulb as the centrally projecting middle tufted cell. The present results, demonstrating the localization of CCK\u2010I to both local circuit and projection neurons of the olfactory bulb and to terminal\u2010like puncta in the internal plexiform and granule cell layers, suggest that CCK may be significantly involved in olfactory processing at several levels.<\/jats:p>","DOI":"10.1002\/cne.902390403","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T16:48:02Z","timestamp":1117212482000},"page":"373-383","source":"Crossref","is-referenced-by-count":96,"title":["Distribution of cholecystokinin\u2010like immunoreactivity in the rat main olfactory bulb"],"prefix":"10.1002","volume":"239","author":[{"given":"Kim B.","family":"Seroogy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Brecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Gall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90050-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902180103"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90849-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90244-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/cne.902040408","article-title":"Localization of methionine\u2010enkephalin, substance P, and somatostatin immunoreactivities in the main olfactory bulb of the hamster","volume":"240","author":"Davis B. 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