{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:18:02Z","timestamp":1789622282813,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":6790,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1986,3,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intraventricular injections of 6\u2010hydroxydopamine in 3\u2010day\u2010old rats resulted in the near\u2010total loss of tyrosine\u2010hydroxylase\u2010immunoreactive processes in the striatum when examined 2\u20106 months later. This destruction of dopamine (DA) afferents was accompanied by an increase in the density of serotonin (5\u2010HT)\u2010immunoreactive fibers in the striatum. The hyperinnervation was most striking in the rostral striatum, an area containing few 5\u2010HT\u2010immunoreactive fibers in control rats. Retrograde tracing, with either horseradish peroxidase or rhodamine\u2010labelled microspheres, indicated a significant increase in the number of neurons projecting to the rostral striatum from the dorsal raphe nucleus of lesioned animals. The increase was largely confined to the rostral extent of the dorsal raphe, and overlapped the distribution of cells labelled after injections of HRP into caudal striatum of control and lesioned animals. In sections additionally processed for immunocytochemistry, 80\u201390% of retrogradely labelled raphe neurons in both groups of animals were found to be 5\u2010HT\u2010immunoreactive. None of changes encountered in infant\u2010lesioned rats were observed 2\u20134 weeks after 6\u2010HDA was given to adult animals. These findings demonstrate that removal of DA afferents during development leads to an enlargement of the serotoninergic projection from the raphe nucleus to the striatum.<\/jats:p>","DOI":"10.1002\/cne.902450209","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T18:18:13Z","timestamp":1104603493000},"page":"274-281","source":"Crossref","is-referenced-by-count":170,"title":["Sprouting of serotoninergic afferents into striatum after dopamine\u2010depleting lesions in infant rats: A retrograde transport and immunocytochemical study"],"prefix":"10.1002","volume":"245","author":[{"given":"Abigail M.","family":"Snyder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Zigmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond D.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/29.6.7252134"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90667-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1152\/physrev.1979.59.1.62","article-title":"Regeneration of monoaminergic and cholinergic neurons in the mammalian central nervous system","volume":"59","author":"Bj\u00f6rklund A.","year":"1979","journal-title":"Physiol. 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