{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:02:39Z","timestamp":1760644959594},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":6644,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The calibers and microtubular content of axons were studied in normal and regenerating fibers of the sural nerve from 17 to 122 days after a lesion of the sciatic nerve of young adult rats. During this period (70\u2013175 days of age), the cross\u2010sectional area of control myelinated axons almost doubled but that of nonmedullated axons did not change. In regenerating nerves, after 122 days of recovery, the cross\u2010sectional area of myelinated fibers was still 38% below that of the normal side. In contrast, the regenerating nonmedullated population was richer in fine (&lt; 0.2 \u03bc<jats:italic>m<\/jats:italic><jats:sup>2<\/jats:sup>) and in coarse (&gt; 0.9 \u03bcm<jats:sup>2<\/jats:sup>) fibers than on the control side; the cross\u2010sectional area averages were 0.50 and 0.54\u20130.70 \u03bcm<jats:sup>2<\/jats:sup> for the normal and regenerating populations, respectively.<\/jats:p><jats:p>The microtubular density of normal 3\u2010\u03bcm myelinated fibers averaged 24.0 microtubules\/\u03bcm<jats:sup>2<\/jats:sup>. In regenerating fibers of the same size the density varied between 19.2 and 23.2 microtubules\/\u03bcm<jats:sup>2<\/jats:sup>. Microtubular density values of normal and regenerating fibers were not statistically different. In nonmedullated fibers, the microtubular content (expressed as microtubular density or number of microtubules per axon) correlated with the caliber of the fiber. In these correlations, only minor differences were observed between regenerating and uninjured fibers.<\/jats:p><jats:p>Our results indicate that nonmedullated fibers terminate their radial growth well before myelinated fibers do, and that axonal microtubular content correlates with the local size of the fiber and is largely insensitive to regeneration.<\/jats:p>","DOI":"10.1002\/cne.902500106","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T20:07:05Z","timestamp":1104610025000},"page":"65-72","source":"Crossref","is-referenced-by-count":23,"title":["Microtubules and calibers in normal and regenerating axons of the sural nerve of the rat"],"prefix":"10.1002","volume":"250","author":[{"given":"Francisco","family":"Espejo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(85)80028-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(83)90397-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90214-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902360209"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902500107"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(85)90121-9"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90014-3"},{"key":"e_1_2_1_9_1","first-page":"1021","volume-title":"Cell Motility","author":"Lasek R. 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Cytol."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000145844"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902220402"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902500106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902500106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T01:29:08Z","timestamp":1697851748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902500106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,8]]}},"alternative-id":["10.1002\/cne.902500106"],"URL":"https:\/\/doi.org\/10.1002\/cne.902500106","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,8]]}}}