{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:26:47Z","timestamp":1791340007905,"version":"4.3.1"},"reference-count":65,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":6484,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1987,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunoreactive luteinizing hormone\u2010releasing hormone (LHRH) was localized in a relatively large number of ganglion cells and fibers of the nervus terminalis of neonatal and adult mice, indicating that this nerve is a substantial source of LHRH in the mouse brain.<\/jats:p><jats:p>Whole\u2010head specimens of neonatal mice, prior to calcification of the cranium, revealed an extensive distribution of LHRH neurons and fine fibers throughout the peripheral, intracranial, and central parts of the nervus terminalis. The most striking difference between the neonatal and adult animals, in the nervus terminalis, was the increase in immunoreactive axons that made up the fiber bundles of this nerve. In the adult mouse, the intracranial and central projections were composed of thick fascicles of immunoreactive axons, ensheathed by glial cells and accompanied by ganglia that contained both LHRH\u2010reactive and nonimmunoreactive neurons. LHRH\u2010immunoreactive cells and axons were seen in a branch of the nervus terminalis that coursed along the medial, posterodorsal aspect of the olfactory bulb and in branches of this nerve that accompany the vomeronasal nerves to the accessory olfactory bulb. A few LHRH neurons and many immunoreactive processes were seen in the accessory and main olfactory bulbs.<\/jats:p><jats:p>LHRH\u2010reactive neurons were seen in the hypothalamus and extrahypothalamic structures. Examination of adult mouse brains revealed a pattern of distribution and number of immunoreactive neurons similar to that seen in the neonate. However, many more LHRH\u2010reactive axons were seen in all areas of the brain of the mature animal.<\/jats:p>","DOI":"10.1002\/cne.902550207","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T20:16:46Z","timestamp":1104610606000},"page":"231-244","source":"Crossref","is-referenced-by-count":54,"title":["Distribution of luteinizing hormone\u2010releasing hormone in the nervus terminalis and brain of the mouse detected by immunocytochemistry"],"prefix":"10.1002","volume":"255","author":[{"given":"Marlene","family":"Schwanzel\u2010Fukuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Soledad","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan I.","family":"Morrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W.","family":"Pfaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001390108"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000144582"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0590223"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901590206"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.131.3412.1526"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/28.4.6989900"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-09-02222.1984"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001550111"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1523\/JNEUROSCI.04-09-02230.1984","article-title":"Pheromonally induced release of luteinizing hormone in male mice: Involvement of the vomeronasal system","volume":"4","author":"Coquelin A.","year":"1984","journal-title":"J. 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