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Heavy autoradiographic labelling was observed at the classical NGF target sites, the proximal cranial sensory ganglia and the sympathetic superior cervical ganglion, throughout development and after hatching. In contrast, only weak Labelling could be detected during a restricted time span in the vestibulocochlear (E4\u2013E8) and the distal cranial sensory ganglia (E4\u2013E10), the neurons of which originate from the otic and epibranchial placodes. Specific <jats:sup>125<\/jats:sup>b\u03033NGF binding was also observed in various brain regions during early brain development. NGF receptor expression there followed a characteristic pattern. The neuroepithelial layer displayed very low levels of specific <jats:sup>125<\/jats:sup>Ib\u0303NGF binding, while strong <jats:sup>125<\/jats:sup>Ib\u0303NGF labelling was found in the mantle layer. Brainstem somatomotor nuclei, visceromotor columns, brain\u2010stem alar plate, cerebellar anlage, tectum, and basal forebrain (epithalamus, striatum) were found to be transiently labelled by <jats:sup>125<\/jats:sup>Ib\u0303NGF in early development (E4\u2013E12). Non\u2010nervous tissues such as parts of the otic vesicle epithelium and skeletal muscle anlagen of the head were also labelled. These results, showing specific binding of <jats:sup>125<\/jats:sup>Ib\u0303NGF to cranial cells of different origin (neural tube, neural crest, placode, and possibly mesoderm) strengthen the concept that NGF may have diverse functions in growth and differentiation of various tissues and cell types.<\/jats:p>","DOI":"10.1002\/cne.902560204","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T20:19:39Z","timestamp":1104610779000},"page":"229-245","source":"Crossref","is-referenced-by-count":72,"title":["Nerve growth factor (NGF) receptor expression in chicken cranial development"],"prefix":"10.1002","volume":"256","author":[{"given":"Gennadij","family":"Raivich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Sutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.451576"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001630407"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.2.1199"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90589-4"},{"key":"e_1_2_1_6_1","first-page":"428","article-title":"Neuroglial development and myelination in the spinal cord of the chick embryo","volume":"5","author":"Bensted J. 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