{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:34:58Z","timestamp":1792276498255,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":6453,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1987,2,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A scanning and transmission electron microscopic study was done of the caudal portion of the fourth ventricular roof in the adult mouse. The caudal portion of the fourth ventricular roof was divided into two parts: choroid plexus and nonchoroid plexus roof. The plexus epithelial cells had numerous microvilli and were connected with each other with a tight junction, gap junction, or zonula adherens. The nonchoroid plexus roof was a thin neuroglial membrane with a continuous basement membrane, which we designated as \u201cthe membranous roof.\u201d The membranous roof was mostly composed of a single layer of paving ependymal cells supported by discontinuous pial cells. The ependymal cells were characterized by their squamous cell configuration, various numbers of microvilli and cilia, and a continuous basement membrane. They were connected with each other by gap junctions or zonulae adherentes, but they lacked tight junctions. Neither a cytoplasmic pore nor a wide intercellular cleft was identified. Neuronal and glial cell processes were occasionally observed. The aperture that is supposed to exist in the caudal, median portion of the fourth ventricular roof of the adult mammalian brains, called the foramen of Magendie in the human brain, was not found. Our observations suggest that the membranous roof itself would permit passage of the cerebrospinal fluid containing macromolecules via the interependymal cell clefts, implying that the foramen of Magendie would not be an anatomical aperture but a functional channel for the outflow of the cerebrospinal fluid.<\/jats:p>","DOI":"10.1002\/cne.902560209","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T20:19:39Z","timestamp":1104610779000},"page":"299-307","source":"Crossref","is-referenced-by-count":14,"title":["Ultrastructure of the caudal portion of the fourth ventricular roof in the mouse"],"prefix":"10.1002","volume":"256","author":[{"given":"Yoshio","family":"Oda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/71.3.281"},{"key":"e_1_2_1_3_1","first-page":"1143","article-title":"Choroid plexus and ventriculus of the brain as a secreting organ","volume":"9","author":"Bland\u2010Sutton J.","year":"1923","journal-title":"Lancet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)64147-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.40.3.648"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01405948"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901410407"},{"key":"e_1_2_1_8_1","volume-title":"Bailey's Textbook of Histology","author":"Copenhaver W. M.","year":"1978"},{"key":"e_1_2_1_9_1","first-page":"954","article-title":"Sur l'absence des trous de Magendie et de Luschka chez quelques mammif\u00e8res. C. R. S\u00e9anc","volume":"83","author":"Coupin F.","year":"1920","journal-title":"Soc. Biol. Paris"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90818-5"},{"key":"e_1_2_1_11_1","first-page":"142","article-title":"The subarachnoid space interpreted as a special portion of the connective tissue space","volume":"24","author":"Frederickson R. G.","year":"1971","journal-title":"Proc. N. Dakota Acad. Sci."},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00233683","article-title":"Continuity between the ventricular and subarachnoid cerebrospinal fluid in an amphibian, Rana pipiens","volume":"195","author":"Jones H. C.","year":"1978","journal-title":"Cell Tissue Res."},{"key":"e_1_2_1_13_1","first-page":"171","article-title":"Comparative aspects of the cerebrospinal fluid systems in vertebrates","volume":"66","author":"Jones H. C.","year":"1979","journal-title":"Sci. Prog."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00234840"},{"key":"e_1_2_1_15_1","first-page":"309","article-title":"Intercellular pores between the ependymal cells lining the roof of the fourth cerebral venticle in mammalian fetuses","volume":"31","author":"Jones H. C.","year":"1980","journal-title":"Z. Kindechir."},{"key":"e_1_2_1_16_1","first-page":"91","article-title":"The ultrastructure of the rhombencephalic posterior tela and adjacent tissues in an amphibian, Rana pipiens","volume":"134","author":"Jones H. C.","year":"1982","journal-title":"J. Anat."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7998.1978.tb03337.x"},{"key":"e_1_2_1_18_1","volume-title":"Medical Embryology","author":"Langman J.","year":"1981"},{"key":"e_1_2_1_19_1","first-page":"B115","volume-title":"Proceedings of the Third Europian Regional Conference on Electron Microscopy","author":"Low F. W.","year":"1964"},{"key":"e_1_2_1_20_1","volume-title":"The Developing Human. Clinically Oriented Embryology","author":"Moore K. L.","year":"1982"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902250310"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197207000-00005"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ar.1091940306","article-title":"Circulation of cerebrospinal fluid in the bullfrog, Rana catesbiana","volume":"194","author":"Torheim P. A.","year":"1979","journal-title":"Anat. Rec."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00220439"},{"key":"e_1_2_1_25_1","first-page":"314","article-title":"Basal lamina scaffold. Anatomy and significance For maintenance of orderly tissue structure. A review","volume":"77","author":"Vracko R.","year":"1974","journal-title":"Am. J. Pathol."}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902560209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902560209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T13:59:39Z","timestamp":1697896779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902560209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,2,8]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,2,8]]}},"alternative-id":["10.1002\/cne.902560209"],"URL":"https:\/\/doi.org\/10.1002\/cne.902560209","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,2,8]]}}}