{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:28:30Z","timestamp":1760297310036,"version":"3.32.0"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":6211,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1987,10,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Defects of the cerebral cortex and corpus callosum of mice subjected prenatally to gamma irradiation were evaluated as a function of dose and of embryonic age at irradiation. Pregnant mice were exposed to a gamma source at 16, 17, and 19 days of gestation (E16, E17, and E19, respectively), with total doses of 2 Gy and 3 Gy, in order to produce brain defects on their progeny. At 60 postnatal days, the brains of the offspring were analyzed qualitatively and quantitatively and compared with those of nonirradiated animals. Mice irradiated at E16 were all acallosal. Those that were exposed to 2 Gy displayed an aberrant longitudinal bundle typical of other acallosals, but this was not the case in those irradiated with 3 Gy. The corpus callosum of animals irradiated at E17 with 3 Gy was pronouncedly hypotrophic, but milder effects were observed in the other groups. Quantitative analysis confirmed a dependence of callosal midsagittal area upon dose and age at irradiation, and, in addition, indicated an interaction between these variables. The neocortex of irradiated animals was hypotrophic: layers II\u2010III were much more affected than layer V, and this was more affected than layer VI. Quantitative analysis indicated that this effect also depended on dose and age at irradiation and that it was due to a loss of cortical neurons. Furthermore, a positive correlation was found between the number of neurons within layers II\u2010III, and V and the midsagittal area of the corpus callosum. Ectopic neurons were found in the white matter and in layer I of animals irradiated at E16 and E17, indicating that fetal exposure to ionizing radiation interfered with the migration of cortical neuroblasts.<\/jats:p>","DOI":"10.1002\/cne.902640205","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T20:41:39Z","timestamp":1104612099000},"page":"193-204","source":"Crossref","is-referenced-by-count":33,"title":["Effects of prenatal irradiation on the development of cerebral cortex and corpus callosum of the mouse"],"prefix":"10.1002","volume":"264","author":[{"given":"Sergio L.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Lent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"147","article-title":"A study of gnosis, praxis and language following section of the corpus callosum and anterior commissure","volume":"160","author":"Akelaitis A. J.","year":"1944","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/cne.901810305","article-title":"Organization of corticocortical connection in the parietal cortex of the rat","volume":"181","author":"Akers R. M.","year":"1979","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/192766b0"},{"key":"e_1_2_1_5_1","first-page":"707","article-title":"The effects of X\u2010irradiation on the development of the cerebral cortex","volume":"100","author":"Berry M.","year":"1966","journal-title":"J. Anat."},{"key":"e_1_2_1_6_1","first-page":"691","article-title":"The migration of the neuroblasts in the developing cerebral cortex","volume":"99","author":"Berry M.","year":"1965","journal-title":"J. Anat."},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.2517-6161.1964.tb00553.x","article-title":"An analysis of transformations","volume":"26","author":"Box G. E. P.","year":"1964","journal-title":"J. R. Stat. Soc.(Ser. B)"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1974.10482955"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1974.10489158"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901640207"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90141-9"},{"key":"e_1_2_1_12_1","first-page":"43","volume-title":"The Developing Brain and its Disorders","author":"Caviness V. S.","year":"1984"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196010000-00002"},{"key":"e_1_2_1_14_1","first-page":"147","article-title":"The fibre\u2010content of the corpus callosum of the albino rat","volume":"160","author":"Cumming W. J. K.","year":"1969","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90116-9"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.15.12.1104"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902120106"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180210"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1979.11739553"},{"key":"e_1_2_1_20_1","first-page":"308","article-title":"The maximum F\u2010ratio as a short cut test for heterogeneity of variances","volume":"37","author":"Hartley H. O.","year":"1950","journal-title":"Biometrika"},{"key":"e_1_2_1_21_1","first-page":"272","article-title":"Developmental malformation produced by radiation","volume":"69","author":"Hicks S. P.","year":"1953","journal-title":"Am. J. Roentgenol. Radium Ther. Nucl. Med."},{"key":"e_1_2_1_22_1","first-page":"363","article-title":"Mechanism of radiation anencephaly, anophthalmia and pituitary anomalies","volume":"57","author":"Hicks S. P.","year":"1954","journal-title":"Arch. Pathol."},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1152\/physrev.1958.38.3.337","article-title":"Radiation as an experimental tool in mammalian developmental neurology","volume":"38","author":"Hicks S. P.","year":"1958","journal-title":"Physiol. Rev."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.141.3584.903"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90247-6"},{"key":"e_1_2_1_26_1","first-page":"53","article-title":"Variability in the distribution of callosal projection neurons in the adult rat parietal cortex","volume":"306","author":"Ivy G. O.","year":"1984","journal-title":"Brain"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901950302"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90118-8"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902090202"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.3.964"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900640210"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-85986-1_14"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902230407"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(86)90159-8"},{"volume-title":"Developmental Neurobiology of Mammals","year":"1987","author":"Lent R.","key":"e_1_2_1_35_1"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315920"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(84)90319-5"},{"volume-title":"Applied Linear Statistical Models","year":"1974","author":"Neter J.","key":"e_1_2_1_38_1"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(82)90181-X"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902140306"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901450105"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)91175-0"},{"key":"e_1_2_1_43_1","first-page":"405","article-title":"Callosal agenesis without the formation of longitudinal bundles as a consequence of gamma\u2010irradiation of mouse fetuses","volume":"17","author":"Schmidt S. L.","year":"1984","journal-title":"Braz. J. Med. Biol. Res."},{"key":"e_1_2_1_44_1","first-page":"487A","article-title":"Callosal and cortical abnormalities induced by prenatal gamma\u2010irradiation","volume":"19","author":"Schmidt S. L.","year":"1986","journal-title":"Braz. J. Med. Biol. Res."},{"key":"e_1_2_1_45_1","first-page":"525","article-title":"Development of neurons in the forebrain of rats following prenatal X\u2010irradiation","volume":"1","author":"Schneider B. F.","year":"1980","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_46_1","first-page":"1503","article-title":"Role of the subventricular zone in growth and guidance of callosal axons","volume":"12","author":"Schneider B. F.","year":"1986","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/52.3-4.591"},{"key":"e_1_2_1_48_1","first-page":"939","article-title":"Ectopic neurons in the brain of the autoimmune mouse: A neuropathological model of dyslexia?","volume":"9","author":"Sherman G. P.","year":"1983","journal-title":"Soc. Neurosci. Abstr."},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902100103"},{"key":"e_1_2_1_50_1","first-page":"273","article-title":"Growth patterns in the lateral wall of the mouse telecephalon I. Autoradiographic studies of the histogenesis of the isocortex and adjacent areas","volume":"134","author":"Smart I. H. M.","year":"1982","journal-title":"J. Anat."},{"volume-title":"Developmental Neurobiology of Mammals","year":"1987","author":"Smith G. M.","key":"e_1_2_1_51_1"},{"volume-title":"Biometry","year":"1981","author":"Sockal R. R.","key":"e_1_2_1_52_1"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(86)80087-0"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90530-7"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(81)90001-8"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901750405"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90688-5"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901680302"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901640206"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902640205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902640205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T06:07:03Z","timestamp":1734847623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902640205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10,8]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,10,8]]}},"alternative-id":["10.1002\/cne.902640205"],"URL":"https:\/\/doi.org\/10.1002\/cne.902640205","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"type":"print","value":"0021-9967"},{"type":"electronic","value":"1096-9861"}],"subject":[],"published":{"date-parts":[[1987,10,8]]}}}