{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T06:02:52Z","timestamp":1751868172146},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":6045,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1988,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies of albino rodents have shown that an absence of pigment in the developing optic stalk may alter the position of the first retinal fibers that grow toward the brain, thereby disrupting the gross topographic relationship of fibers in the nerve (Silver and Sapiro: <jats:italic>J. Comp. Neurol. 202<\/jats:italic>:521\u2013538, \u203281). The abnormalities associated with albinism are more extensive in the Siamese cat than in previously studied species. Therefore, any abnormalities in differentiation of the stalk and axon guidance may be more readily detected. To investigate the guidance and\/or misguidance of optic axons, light and electron microscope analyses were made of serial sections through the optic stalk in normally pigmented and Siamese fetal cats.<\/jats:p><jats:p>On E20, before axons enter the optic stalk, the only clear morphological distinction between Siamese and normal cats is the distribution of pigment in the stalk. Pigment is found in the dorsal stalk cells of the normal cat for 200 \u03bcm from the optic disc. Although the retinal pigment epithelium of the Siamese cat embryo contains pigment, pigment could not be detected in the Siamese optic stalk. By E23 axons invade the ventral optic stalk in both strains. Concurrent with the early stages of axonal exit from the retina, there is complete separation of the stalk's dorsal and ventral tiers. As the cleavage occurs, basal lamina invaginates into the zone of separation following along the plane of the old lumen. The ventral stalk fills with axons while the dorsal tier is shed gradually. In contrast, in the Siamese cat, dorsal stalk cells are not sloughed off properly and instead are incorporated ectopically into the nerve. Basal lamina invagination is irregular. Axons do not fill the Siamese stalk symmetrically but enter the region of ectopic cells, which in turn disrupts gross fiber position. Usually, in the mutant, axons originating from the retina temporal to the optic fissure are those that invade the dorsal tier of ectopic cells. The altered position of optic axons in the mutant stalk may provide an explanation for the chiasmatic misrouting of optic axons in this species.<\/jats:p>","DOI":"10.1002\/cne.902690409","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T18:48:58Z","timestamp":1104605338000},"page":"592-611","source":"Crossref","is-referenced-by-count":25,"title":["Abnormal pigmentation and unusual morphogenesis of the optic stalk may be correlated with retinal axon misguidance in embryonic siamese cats"],"prefix":"10.1002","volume":"269","author":[{"given":"M. J.","family":"Webster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Shatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kliot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Silver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.104.6.1587"},{"key":"e_1_2_1_3_1","first-page":"85","article-title":"On the development of the optic nerve of vertebrates, and the choroidal fissure of embryonic life","volume":"34","author":"Assheton R.","year":"1892","journal-title":"Q. J. Microsc."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.001513"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/cne.902150402","article-title":"Studies on cell migration and axon guidance in the developing distal auditory system of the mouse","volume":"225","author":"Carney P. R.","year":"1983","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1083\/jcb.91.1.157","article-title":"Influence of collagen gel on the orientation of epithelial polarity: Follicle formation from isolated thyroid cells and from preformed monolayers","volume":"92","author":"Chambard M.","year":"1981","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/cne.901870205","article-title":"The retinothalamic pathways in Siamese cats","volume":"287","author":"Cooper M. L.","year":"1979","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901660406"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.02-07-00907.1982"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.684419"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1984.0087"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90607-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901910306"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.19.6716"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1242\/jcs.22.3.585","article-title":"A decay in gap junctions associated with cell differentiation of neural retina in chick embryonic development","volume":"22","author":"Fujisawa H.","year":"1976","journal-title":"J. Cell Sci."},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1242\/jcs.1986.Supplement_4.14","article-title":"Desmosomes, cell adhesion molecules and the adhesive properties of cells in tissues","volume":"4","author":"Gaarod P. R.","year":"1986","journal-title":"J. Cell Sci. [Suppl."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901360107"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)91172-5"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(69)90213-3"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0574-44"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4011.831"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901430106"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/252195a0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0165-3806(85)90158-0","article-title":"On the distribution and probable origin of axon bundles in the pigment epithelium of the eyecup","volume":"17","author":"Guillery R. W.","year":"1985","journal-title":"Dev. Brain Res."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901850404"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902260203"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(84)90199-4"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00346289","article-title":"The distribution of intercellular gap junctions in the developing retina and pigment epithelium of Xenopus laevis","volume":"150","author":"Hayes B. P.","year":"1976","journal-title":"Anat Embryol. (Berl."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902430409"},{"issue":"13","key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/282720a0","article-title":"Non\u2010retinotopic arrangement of fibers in cat optic nerve","volume":"282","author":"Horton J. C.","year":"1979","journal-title":"Nature"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1960.sp006596"},{"issue":"10","key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1523\/JNEUROSCI.05-10-02641.1985","article-title":"Abnormal development of the retinogeniculate projection in Siamese cats","volume":"5","author":"Kliot M.","year":"1985","journal-title":"J. Neurosci."},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.1073\/pnas.82.18.6330","article-title":"Transplants of Schwann cell cultures promote axonal regeneration in the adult mammalian brain","volume":"52","author":"Kromer L. F.","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.104.6.1597"},{"issue":"10","key":"e_1_2_1_35_1","first-page":"732","article-title":"Development of the optic nerve of the rat","volume":"14","author":"Kuwabara T.","year":"1975","journal-title":"Invest. Opthalmol."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901820304"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1523\/JNEUROSCI.02-08-01024.1982","article-title":"Morphology and distribution of retinal ganglion cells projecting to different layers of the dorsal lateral geniculate nucleus in normal and Siamese cats","volume":"2","author":"Leventhal A. G.","year":"1982","journal-title":"J. Neurosci."},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","unstructured":"Liesi P. andJ.Silver(1988) Is astrocyte\u2010laminin involved in axon guidance in the mammalian CNS?Dev. Biol.(In press).","DOI":"10.1016\/0012-1606(88)90366-1"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3691.1506"},{"key":"e_1_2_1_40_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000121618","article-title":"Characteristics of nasal and temporal retina in Siamese and normally pigmented cats","volume":"27","author":"Murakami D.","year":"1982","journal-title":"Brain Behav. Evol."},{"key":"e_1_2_1_41_1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/cne.902510308","article-title":"Course of retinogeniculate projection fibers in the cat optic nerve","volume":"257","author":"Naito J.","year":"1986","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00318985"},{"key":"e_1_2_1_43_1","first-page":"174","article-title":"Distribution of axons in albino and pigmented embryonic optic stalks","volume":"20","author":"Oberdorfer M.","year":"1981","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67681-9_5"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01153497"},{"key":"e_1_2_1_46_1","first-page":"319","article-title":"On the formation and structure of the optic nerve, and its relation to the optic stalk","volume":"30","author":"Robinson A.","year":"1896","journal-title":"J. Anat. Physiol. (Lond."},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901540302"},{"key":"e_1_2_1_48_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1101\/SQB.1983.048.01.060","article-title":"Cell\u2010type specificity and developmental expression of neural cell\u2010surface components involved in cell interactions and of structurally related molecules","volume":"45","author":"Schachner M.","year":"1983","journal-title":"Cold Spring Harbor Symp. Quant. Biol."},{"key":"e_1_2_1_49_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/cne.901710206","article-title":"A comparison of visual pathways in Boston and Midwestern Siamese cats","volume":"271","author":"Shatz C. J.","year":"1977","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-03-00482.1983"},{"issue":"9","key":"e_1_2_1_51_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/300525a0","article-title":"Prenatal misrouting of the retinogeniculate pathway in Siamese cats","volume":"300","author":"Shatz C. J.","year":"1982","journal-title":"Nature"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902230207"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(79)90252-5"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(84)90248-3"},{"key":"e_1_2_1_55_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/cne.902020406","article-title":"Axonal guidance during development of the optic nerve. The role of the pigment epithelia and other extrinsic factors","volume":"205","author":"Silver J.","year":"1981","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_1_56_1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/cne.901800409","article-title":"The nasotemporal division of retina in the Siamese cat","volume":"1080","author":"Stone J.","year":"1978","journal-title":"J. Comp. Neurol."},{"issue":"11","key":"e_1_2_1_57_1","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1523\/JNEUROSCI.01-11-01193.1981","article-title":"The distribution of melanin in the developing optic cup and stalk and its relation to cellular degeneration","volume":"1","author":"Strongin A. C.","year":"1981","journal-title":"J. Neurosci."},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902110405"},{"key":"e_1_2_1_59_1","first-page":"25","article-title":"Retinotopic scatter of optic tract fibers in the cat","volume":"52","author":"Voight T.","year":"1983","journal-title":"Exp. Brain Res."},{"key":"e_1_2_1_60_1","unstructured":"Webster M. J.(1985)Cytogenesis Histogenesis and Morphological Differentiation of the Retina. Ph.D. thesis University of New South Wales Sydney Australia."},{"key":"e_1_2_1_61_1","first-page":"109","article-title":"Developemnt of retinal topography in albino and pigmented rats","volume":"19","author":"Webster M. J.","year":"1985","journal-title":"Neurosci. Lett. [Suppl.]"},{"key":"e_1_2_1_62_1","unstructured":"Webster M. J. andM. H.Rowe(1988) Altered timing of the developmental processes in albino rat retina.J. Comp. Neurol.(in press)."},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902460104"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(76)90054-6"},{"key":"e_1_2_1_65_1","first-page":"313","article-title":"An experimental anatomical study on the topographic termination of the optic nerve fibers in the rat","volume":"22","author":"Yamadori T.","year":"1981","journal-title":"J. Hirnforch."}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.902690409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.902690409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T17:48:00Z","timestamp":1697910480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.902690409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3,22]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,3,22]]}},"alternative-id":["10.1002\/cne.902690409"],"URL":"https:\/\/doi.org\/10.1002\/cne.902690409","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,3,22]]}}}